Blood and Lymphatic disorders Flashcards
1
Q
3 main functions of the blood
A
- distribution
- regulation
- protection
2
Q
Distribution
A
- O2 and nutrients
- hormones
- metabolic waste
3
Q
Regulation
A
- fluid volume
- body temperature
- ph in body tissues
- bicarb ions
4
Q
Protection
A
- WBCs, antibodies to fight infection
- platelets and plasma prevent blood loss
5
Q
haemeostasis
A
clotting cascade - coagulation
6
Q
5 steps of haemostasis
A
- Vascular spasm
- platelet plug formation
- coagulation
- clot retraction and repair
- fibrinolysis
7
Q
vascular spasm
A
injury to endothelium - release endothelin - contracts smooth muscle - pain and vasoconstriction
8
Q
platelet plug formation
A
damaged endothelial cells - VWF released - binds platelets.
secretion of ADP, TXA2 & Seretonin
9
Q
what do platelets bind together with
A
fibrinogen
10
Q
what chemicals enhance vascular spasm?
A
TXA2 & Seretonin
11
Q
2 parts of clotting cascade
A
Intrinsic and extrinsic
12
Q
contact activation
A
Intrinsic pathway
13
Q
tissue factor
A
extrinsic pathway
14
Q
trauma activates clotting factor ..
A
VII into VIIa
15
Q
extrinsic pathway
A
-15 secs to activate
- trauma
- direct trauma releases factor III
