Blood and haemostasis Flashcards
State the functions of the blood
Transports heat around the body
Supplies oxygenated blood to respiring tissues
Transports carbon dioxide from tissues to the lungs
Transports hormones to target organs
Nutrients from digestion transported in the blood
Delivery of waste to excretory organs
Regulates osmotic pressure
Carries WBC and platelets involved in tissue repair and inflammation
Describe the composition of blood
Blood is a connective tissue, plasma makes up 55% of blood, 45% RBC, platelets and WBC
What is the concentration of RBC in males and females?
Males: 42-52%
Females:37-47%
What is Polycythaemia?
The thickening of the blood caused by overproduction of RBC from bone marrow, a form of blood cancer
What is anaemia?
Lack of functioning RBC, leads to less O2 carried in the blood,
Colour of blood in humans & most vertebrates?
RED, bright red in arterial blood and a darker colour in venous blood, as Hb contains Fe prosthetic group giving colouration
Colour of blood in crustaceans, squid & octopi?
Blue, as it contains hemocyanin which floats freely in the blood, has Cu prosthetic group, oxygenated it is blue, deoxygenated it is colourless
Colour of blood in worms & leeches?
Green as they contain chlorocruorin, which is light green when deoxygenated and a deeper green when oxygenated, some species contain Hb
Colour of blood in penis worms, peanut worms & brachiopods
Purple, it contains hemerythrin, which is less efficient than Hb, colorless when deoxygenated and lilac when oxygenated
Describe the components in blood plasma?
Makes up 55% of blood. 90% is made of water, 10% dissolved ions, proteins etc,
pH of 7.4, transports heat, nutrients or waste where they need to be
Plasma produces fibrinogen involved in blood clotting
Carries antibodies, albumin involved in osmotic pressure
7% is made in liver, drop in plasma proteins is detected by liver, liver produces more
Describe the structure & function of RBC
Known as erythrocytes, small, biconcaves giving a large SA:vol, allow rapid diffusion. Flexible enabling it to squeeze through gaps in capillaries
Has 4 Fe groups per Hb
Has 250-280 million Hb molecules per RBC
No nucleus, mitochondria or ER, so more space for Hb, the short life span of 120 days, broken down in the liver, made in bone marrow, respires anaerobically
Define isotonic state of RBC
Where the concentration of water is equal both in & outside of cell, RBC is normal shape & size
Define hypotonic state of RBC
RBC swells as the concentration of water is greater outside of the cell, causing water to move in via osmosis, causing swelling, could lead to bursting of cell
Define Hypertonic state of RBC
Where concentration of water is greater inside the cell, so water moves out of the RBC, leaving it to become crenated, reduces SA, cytoskeleton sticks out giving spikey appearance
Describe role of WBC
Involved in fighting infection and the immune response
5 types of WBC, can be divided into 2 groups agranulocytes (normal nucleus & agranular cytoplasm) and granulocytes (multi-lobed nucleus & granular cytoplasm)