Blood Flashcards
Types of bleeding disorder
Vascular disorder
Thrombocytopenia’s
Defective platelet function
Defection coagulation
Common symptoms of bleeding disorders
External : petechia (small blood spots on skin)
Ecchymosis
Hematoma
Clinic symptoms of bleeding disorder
Epistaxis (nose bleeds)
Gingival bleeding
Bruising
Purapua
Menorrhagia
Joint bleeds
Muscle bleeds
Chronic anemia
Thrombocytopenia
Reduced platelet count, quantitative disorder, if too less means significant amount of ponatenous bleeding.
Thrombocytopenia causes
Systemic causes-
Autoimmune disorder
Drug-induced such as heparin-induced thrombosis
Vaccine induced thrombosis
Other factors such as bone marrow alterations, infections, preach, surgical implications
Inherited platelet disorders
Affecting ahedsio, secretion, aggregation
Bernard-soulier syndrome, Glanzmann thrombasthenia, Herman sky-pudlak Syndrom, gray platelet syndrome
Specific conditions abusing oagualtiondisorders
Qlualitive and quantitative
Disseminated intravascular coagulation such as inappropriate blood coagulation actvation
Vitamin k difficiency essential for protein carboxylaton) affecting II VII IX X and inhibitors Protien C,S, Z
What values vitamin K difficiency
Malabsorption, anticoagulation therapy, liver disease, dietary factors, newborn vulneribility
Inherited bleeding disorders
Haemophilia A- VIII difficency
Häemphillia B - XI difficiency
IF too severe causes spontanos joint bleeds, moderate - bleeding after minor trauma , mild insist increased bleedig
Von Wille Brand disease
Inherited disease
Type 1 partial qunatitive difficiency
Type 2 quantities difficiency
Tpe 3 total factor difficiency
Treated by : factor replacement, desmopressin, platelet transfusion, target factor concentrations
What happens if u have microcytic anaemia
Iron deficiency
Thalasseamia
Anaemia
Lead posionoing
