Blood Flashcards
What does plasma consist of and what percent of the blood is plasma?
. Mainly consists of water and solutes such as electrolytes, nutrients, hormones etc. 55%. Of blood
What are leukocytes, erythrocytes and platelets
Cells in the blood: while, red and platelets help with repairs/coagulation
Function of erythrocytes/hemoglobin
Red blood cell ( RBC) consist of hemoglobin and iron binding heme proteins
Produces oxyhemoglobin which binds hemoglobin with Oz (loading of oxygen in lungs)
Produces deoxyhemoglobin, this is when oxygen detaches from hemoglobin and uploaded oxygen to tissues
Explain hematopoiesis
The formation of blood cells occurs in red bone marrow and starts with hematopoietic (red blood) stem cells, then mature red blood cells cross porous walls to blood
Explain EPO negative feedback
Stimulus: hypoxia (aka luck oxygen from low RBC count for example)
Kidney releases EPO
EPO stimulates red bone narrow
Enhanced erythropoeisis increase RBC count
Oxygen is then being circulated adequately
How long to RBC’s live for and what happens at the end of their life
They live for 120 days and the macrophages of the spleen engulf them and hemoglobin breaks down
Explain the coagulation process
After platelets clump together to form a plug ) fibrin proteins form a mesh that that traps RBC’s and platelets to form a dot
Intrinsic pathway vs extrinsic pathway
Intrinsic pathway is clotting within blood (such as internal damage to vascular ‘ endothelium) whereas extrinsic is activated by external trauma. They use different preliminary factors but end with factor 10 aka prothrombin transforms to thrombin and thrombin converts fibrinogen to fibrin fibrin creates the net
What is thromboembolic disorder
Too much blood clotting
What causes bleeding disorders
Abnormalities that stop clothing ( not enough clothing)
Thrombus vs embolism
Thrombus = unnecessary clot but no block
Embolism= clot and blocked
What plasma antibodies would type B have?
Anti-a
