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Pharmacology > Blood > Flashcards

Blood Flashcards

1
Q

Ttt of sphyrocytosis anemia…….

A

Partial or total splenoectomy

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2
Q

Ttt of hemolytic anemia (d.t G6PH deficiency is done by………

A

Avoiding oxidants such as :
Food (beans)
Drugs ( primaquine or antimalarial)

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3
Q

Ttt of osteoarthritis

A
  1. Analgesics
  2. Chondrotin and glycosamine

N.B steroids are not used ( because it is not an autoimmune disease)

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4
Q

Rheumatoid heart fever is diagnosed by……

A

ECA antibodies and rheumatoid factors

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5
Q

Urinary tract infection caused by gram negative bacteria such as :

A

E. Cloi
Klebsilla
Pseudomonas
Proteus mirabilis

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6
Q

Pancreatitis diagnosed by………..

A

⬆️Of lipase and amylase

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7
Q

Ttt of Utrinary tract infection by :
1.
2.
3.
4.

A
  1. Carbencillin
  2. Ticarcillin
  3. Cyprofloxacin
  4. Cephalexin
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8
Q

Fresh Frozen plasma contains all plasma ptn and clotting factors (T or F)

Cryoprecipitate contains fibrinogen (T or F)

A

Both are true

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9
Q

Bleeding time influenced by………
Prothrombin time influenced by…….
Clotting time or partial thromboplastin time are influenced by….

A

Aspirin

Warfarin

Heparin

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10
Q

Clopidogrel is used as……..
Dipyridamol action is………….and………… It’s used in ttt of…….that occurs in arteries.

A

Antiplatelet

Vasodilators and antiplatelet
Tt peripheral vascular diseases

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11
Q

Antidote of streptokinase is

A

Tranexamic acid

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12
Q

Burger’s disease is tt by……..

A

Stop smoking

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13
Q

Alteplase does not have antidote (T or F)

A

T

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14
Q

Iron deficiency anemia is tt by:
1.
2.

A
  1. Ferrous gluconate, ferrous sulphate, ferrous fumarate
  2. Parenterally iron (iron isomaltose or iron carboxymaltose)
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15
Q

Anemia of chronic disease is tt by……

A

Treating the underlying cause

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16
Q

Examples of hemolytic anemia are spherocytosis or G6PD deficiency (T or F)

A

True

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17
Q

S.E of primaquine (antimalarial drug) is…….

A

Visual disturbances

Same as Ivabradine and Ethambutol

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18
Q

PNH or morning haematouria is tt associated with………..and……….,but the ttt is done by:
1.
2.

A

Pancytopenia and thrombosis

  1. Eculizumab (anti-C5)
  2. Anticoagulant
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19
Q

Ttt of sickle cell anemia
1.
2.
3.
4.

A
  1. Hydroxy urea or hydroxycarbamide
  2. Treat the crisis by O2, antibiotics, fluids
  3. Blood transfusion
  4. Splenoectomy
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20
Q

Ttt of mild thalassemia by…….
Ttt of severe anemia by…….

A

Folic acid

Blood transfusion

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21
Q

Folic acid defeciency anemia is tt by…….

A

Folic acid supplements

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22
Q

Autoimmune hemolytic anemia and Immune thrombocytopenia purpura are tt by…………

A

Corticosteroids (hydrocortisone and prednisolone)

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23
Q

Ttt of PRV(polycythemia rubra vera) by……….,………&……….

A

Aspirin, venesection& anticancer drugs

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24
Q

Essential thrombocythemia is tt by………..and………

A

Aspirin and anticancer drugs

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25
Q

Gastric lymphoma reversible is tt by………..

A

PPI

Caused by H. Pylori

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26
Q

Ttt of nausea and vomiting after chemotherapy done by………or………

A

Ondansetron or dexamethasone

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27
Q

S. E of cyclophosphamide(link adjucent guanine) is………which tt by……..and……..

A

Hemorrhagic cystitis (acroline bind with - SH)

Tt by fluid and MSNA

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28
Q

S.E of methotrexate :
1.
2.
3.

A
  1. Pulmonary fibrosis
  2. Teratogenic
  3. Megaloblastic anemia
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29
Q

S.E of BXR and DNR is……….

A

Cardiac myopathy

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30
Q

S.E of Bleomycin is…….

A

Pulmonary fibrosis

31
Q

S.E of vincrystine (defect microtubules during M phase) is…………

A

Peripheral neuropathy or neurotoxicity which l.t numbness and paresthesia

32
Q

Hormonal anti-cancer drugs :

A

Prednisolone (for ALL, CLL, Non-hodging lymphoma)
Estrogen
Androgen
Tamoxifen
Flutamide

33
Q

………….act as aromatase inhibitor l.t decrease formation of Estrogen

A

Anastrazole

34
Q

Biological anti-cancer drugs :

A

Trastuzumab and Imatinib

35
Q

……..act as tyrosine inhibitor, and used in ttt of……..

A

Imatinib

CML

36
Q

………..is teratogenic drug that used in multiple myeloma

A

Thalidone

37
Q

Drugs that cause pulmonary fibrosis 1.
2.
3.

A
  1. Methotrexate
  2. Bleomycin
  3. Amiodarone
38
Q

Cardiac toxicity is a side effect of :
1.
2.
3.

A
  1. Daunorubicine
  2. Doxorubicine
  3. Trastuzumab
39
Q

Abciximab is used in……..and………

A

Acute coronary syndrome and PCI

Bleeding is s.e

40
Q

MOA of adalimumab is……….. And used in ttt of……….and……….
And its S.E is………….

A

Anti-TNF

Ttt of IBD and Rheumatoid arthritis
S.E is ⬇️ immunity

41
Q

IBD is tt by:
1st choice is…….
2nd choice is……..
3rd choice is…….

A

1sr. Amino salicylate
2nd. Steroids
3rd. Adalimumab

42
Q

Alemtuzumab is used for ttt of………

A

Multiple sclerosis

43
Q

Cetuximab act as………….and is used for ttt of………

A

Anti epidermal growth factor

Tt colorectal cancer

44
Q

RANKL (which stim. osteoclast) is prevented by……..

A

Denosumab

It’s not DOC in case of Osteoporosis

45
Q

DOC in Osteoporosis is………

A

Bisphosphonate (alenodronate or pamidronate)

46
Q

Eculizumab is used in ttt of……

A

PNH

47
Q

Infliximab is act as……..

A

Anti-TNF

48
Q

Mepolizumab and omalizumab are used in………

A

Resistant asthma

49
Q

Natalizumab acts as…………… And used in………….

A

Anti a4 & anti B1 on lymphocytes

Used in demylination condition

50
Q

…….used as anti respiratory syncytial virus that cause bronchiolitis

A

Palivizumab

51
Q

……………. acts as anti VEGF, and used in case of……..

A

Ranibizumab

Used in macular degeneration

52
Q

……… act as anti CD20, and used in……….,………… &…………

A

Rituximab

resistant rheumatoid arthritis, CLL & Non-Hodgkins lymphoma

53
Q

………. act as anti IL-6, and used in ttt of………..

A

Tocilizumab

Ttt if resistant rheumatoid arthritis

54
Q

……..act as anti HER_NEU, and used in case of…….

A

Trastuzumab

Metastasis breast cancer

55
Q

…….. acts as antidote of “xaban” family

A

Andexanet

56
Q

……acts as Anti-IL1, and used in……….and………..

A

Anakinra

Tt rheumatoid arthritis (last DOC) and FMF (2nd DOC after Colchicine)

57
Q

Colchicine is used as DOC in………,……….,………

A

Pseudogout, pericarditis, FMF

58
Q

Calcium blocker that act on sk.m is……….

A

Dantrolene

59
Q

……….act as multiple Tyrosine kinase inhibitor, and used in…….and…….

A

Sorafenib

Renal cell carcinoma and hepatocellular carcinoma

60
Q

Bacillus calmette guerin is a vaccine of TB used in bladder cancer (T or F)

A

True

61
Q

……..acts as anti proteosome and used in ttt of……..

A

Bartezomib

Tt multiple myeloma

62
Q

Drugs that act as glycoprotein 2b 3a receptor inhibitor are:
1.
2.
3.

A
  1. Abciximab
  2. Tirofiban
  3. Eptifibatide
63
Q

Hyperlipidemia + Gout tt by

A

Fenofibrate

64
Q

Ttt of Hodgkins lymphoma :

A

(ABVD)
Adriamycin
Bleomycin
Vincristine
Dacarbazine

65
Q

Ttt of Non-Hodgkins lymphoma :

A
  1. Low grade drugs (R-CVP):
    rituximab
    Cyclophosphamide
    Vincristine
    Prednisolone
  2. High grade drugs (R-CHOP) :
    rituximab
    Cyclophosphamide
    Hydroxyuroubincin
    Oncovin
    Prednisolone
66
Q

Ttt of symptoms of multiple myeloma is done by……………………
And its S.E :

A

Bisphosphonate (PRAZE dronate)

S. E:
Irritation of esophagus
GIT disturbances
Peptic ulcer

67
Q

Drugs of Osteoporosis :

A

Bisphosphonate and calcitonin

68
Q

Drugs of hypercalcemia :

A

Bisphosphonate
Calcitonin
Normal saline
Frusemide

69
Q

Ttt of malignant multiple myeloma itself is done by :

A
  1. Bortezimib
  2. Thalidomide (inh. tumor angiogenesis)
  3. Dexamethasone

Lenalidomide instead of thalidomide

70
Q

S.E of thalidomide :
Instead of it we use…..

A
  1. Short extremities
  2. Venous thrombosis
  3. Behcet’s syndrome
  4. Pulmonary embolism

Lenalidomide

Both Lenalidomide and thalidomide are C.I in pregnancy

71
Q

Methotrexate is used in

A

Anti-cancer
IBD
Rheumatoid arthritis

72
Q

S. E of hydroxychloroquine is….

A

Retinopathy

73
Q

S. E of slfasalazine

A

Pancreatitis

74
Q

S. E of antimalarial drugs

A

Cinchonism, its symptoms :
Tinnitus
Vomiting
Nausea
Vertigo
Dizziness

Pharmacology (7 decks)

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