Blood Flashcards
What is hemopoiesis?
Hemopoiesis is the production of blood cells and platelets in response to physiological or pathological stimuli.
What is anemia? What can it result in?
Anemia is when the body doesn’t have enough red blood cells. Can result in increased HR, angina attack, chest pain, enlarged spleen, paleness and feeling cold.
What is the blood composed of?
The blood is composed of; hematocrit, RBC, WBC and platelets.
What is anemia?
Anemia is when there is too few red blood cells.
What is thrombocytopenia?
Thrombocytopenia is when there are too few platelets and clots can’t form.
What is polycythaemia?
Polycythaemia is too many red blood cells, which causes bruising and epistaxis (nosebleeds).
What are the target sites of red blood cells during early development?
The target sites of red blood cells during early development are; the placenta, AGM, umbilical cord, yolk sac and liver.
What are the target sites of red blood cells in adults?
The target sites of red blood cells in adults are the spleen, thymus and bone marrow.
The spleen destroys the old blood cells. White blood cells are produced in the bone marrow and matured in the thymus.
How are stem cells activated?
Stem cells are activated by circulating factors, the biophysical microenvironment and by cytokines.
How can biomarkers be used in cell marking?
Can determine the cell type by patterns and receptors on the cell surface. Via the use of fluorescence activated cell sorting - FAC. Detector looks at fluorescent signals on antibodies that bind to different receptors, producing different colours per receptor. This creates a duel biomarker expression on a graph.
What can monocytes develop into?
Monocytes develop into dendritic, macrophages and microglial.
