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MJ- P2 E2 > Blocking Drugs - 2 > Flashcards

Blocking Drugs - 2 Flashcards

1
Q

What are the 6 inhaled anesthetics?

A

Desflurane

Enflurane

Halothane

Isoflurane

Sevoflurane

Nitrous oxide

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2
Q

Facilitate GABA-mediated inhibition: block brain NMDA and ACh-N receptors

MOA of which drug?

A

All inhaled anesthetics

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3
Q

inhaled anesthetics increase ___________.

A

inhaled anesthetics increase cerebral blood flow.

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4
Q

Which two drugs decrease cardiac output?

All others cause vasodilation

A

enflurane & halothane

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5
Q

all inhaled anesthetics decrease ________.

A

all inhaled anesthetics decrease respiratory functions.

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6
Q

Which drug causes lung irritation?

A

desiflurane

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7
Q

Rate of onset and recovery vary by blood: gas partition coefficient

recovery mainly due to redistribution from brain to other tissues

P-kinetics of which drug?

A

inhaled anesthetics

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8
Q

What are the toxicities of inhaled anesthetics?

A

extensions of effects on brain, heart/vasculature, lungs.

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9
Q

What are the drug interactions of inhaled anesthetics?

A

additive CNS depression with many agents, especially opioids and sedative-hypnotics

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10
Q

What plays an important role in the practice of modern anesthesia?

A

IV non-opioid anesthetics

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11
Q

Used to facilitate rapid induction of anesthesia and have replaced inhalation as the preferred method of anesthesia induction in most settings except for pediatric anesthesia

Which drugs?

A

IV Anesthetics

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12
Q

Provide sedation during monitored anesthesia care and for patients in intensive care (ICU) settings.

Which drug?

A

IV Anesthetics

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13
Q

Not ideal anesthetic drugs in the sense of producing all and only the five desired effects (unconsciousness, amnesia, analgesia, inhibition of autonomic reflexes, and skeletal muscle relaxation)

Which drug?

A

IV Anesthetics

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14
Q

What 4 drugs facilitate GABA-mediated inhibition of Gaba-A receptors?

A

Barbiturates, benzodiazepines, etomidate, and propofol

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15
Q

facilitate GABA-mediated inhibition at GABAA receptors

MOA of which drug?

A

Thiopental, Thioamylal, Methohexital

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16
Q

Pharmacologic effects of Thiopental, Thioamylal, Methohexital (Barbiturates)

A

Circulatory and respiratory depression

decrease intracranial pressure

17
Q

High lipid solubility—fast onset and short duration due to redistribution

PK of which drug?

A

Barbiturates:

Thiopental, Thioamylal, Methohexital

18
Q

Extensions of CNS depressant actions

additive CNS depression with many drugs

Toxicities and Interactions of which drug?

A

Barbiturates:

Thiopental, Thioamylal, Methohexital

19
Q

Slower onset, but longer duration than barbiturates

Which drug?

A

Midazolam

20
Q

Postoperative respiratory depression reversed by flumazenil

Toxicities and Interactions of which drug?

A

Midazolam

21
Q

Blocks excitation by glutamate at NMDA receptors

MOA of which drug?

A

Ketamine

22
Q

What are the pharmacologic effects of ketamine?

A

analgesia, amnesia and catatonia but consciousness retained

CV stimulation

23
Q

PK of ketamine?

A

Moderate duration of action—hepatic metabolism

24
Q

Pharmacologic effects of Etomidate

A

Minimal effects on CV and respiratory functions

25
Q

PK of Etomidate

A

Short duration due to redistribution

26
Q

What are the 4 opioids?

A

Fentanyl

 Alfentanil

 Remifentanil

 Morphine

27
Q

Interact with μ, κ, and δ opioid receptors

MOA of which drug?

A

Opioids:

Fentanyl

 Alfentanil

 Remifentanil

 Morphine

28
Q

Pharmacologic Effects of Opioids

A

Marked analgesia, respiratory depression

29
Q

PK of opioids

A

Alfentanil and remifentanil: fast onset (induction)

30
Q

What are the 2 phenols?

A

Propofol

Fospropofol

31
Q

Vasodilation and hypotension • negative inotropy. Fospropofol water-soluble

Pharmacologic effects of which drug?

A

Propofol, Fospropofol

32
Q

PK of Phenols (Propofol, Fospropofal)

A

Fast onset and fast recovery due to inactivation

33
Q
A

MJ- P2 E2 (19 decks)

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