Antiemetic popcorn Flashcards
What 4 receptors are involved in the “Chemoreceptor trigger zone”
D2 (dopamine)
opioid
5-HT3 (serotonin)
NK1 (neurokinin)
Which 2 receptors are involved in the vestibular system
M1 and H1
Involved in motion sickness
(“Meghan Markle and Prince Harry get motion sickness”)
Which receptor is in the vagal and spinal afferent nerves in the GI tract
5-HT3
(so not involved in motionsickness)
T/F: complex N/V is resolved with antiemetics
false
What are the 4 Selective Serotonin 5-HT3 receptor antagonists?
- Granisetron
- Ondansetron
- Dolasetron
- Palonosetron
(“Palo GOD”)
Which Selective Serotonin 5-HT3 receptor antagonist causes QT prolongation
Dolasetron
Which Selective Serotonin 5-HT3 receptor antagonist do you have to decrease in liver problems
Ondansetron
What are the 2 uses of Selective Serotonin 5-HT3 receptor antagonists? What is it not useful for (2)?
- Uses: Chemo, post-op
- NOT FOR MOTION SICKNESS
- NO use for N/V 24hrs after chemo
Is dose reduction of Selective Serotonin 5-HT3 receptor antagonists required in geriatric patients with renal insufficiency?
no
How do you increase efficacy of Selective Serotonin 5-HT3 receptor antagonists?
add corticosteroid
What are the 2 ADEs of Selective Serotonin 5-HT3 receptor antagonists
HA
constipation (slow GI motility)
What are the 2 Substance P/NK1 receptor antagonist meds?
Aprepitant
Rolapitant
What are Substance P/NK1 receptor antagonists used for?
Delayed emesis
How do you treat acute and delayed emesis?
Substance P/NK1 receptor antagonists + Selective seretonin receptor blocker
= Netupitant + Palonosetron
Which group of meds have hiccups as a SE?
Substance P/NK1 receptor antagonists
(Aprepitant, Rolapitant)