Block A+B Flashcards
what is a drug
a substance that modifies the activity of living tissue
what is physiology
the science of how living tissues function
what are therapeutics
the study of the use of pharmacological agents in disease states
what is pathology
the study of how the body goes wrong in disease states
what is an agonist
affinity- binding of agonist to its receptor
efficacy- ability of agonist to activate the receptor
what is an antagonist
when drugs counteract each other by acting on the same receptor type
what is irreversible-competitive antagonism
in some cases the bond between the antagonist and the receptor is so strong that even increasing concentrations of agonists cannot displace the antagonist. This is often due to covalent bonding
what is non-competitive antagonism
Antagonists which act at sites other than the agonist binding site are classified as non-competitive antagonists.
what is latrogenicity
the capacity to produce disease from the side effects or inappropriate prescribing of drugs
what is tetratogenicity
the capacity to produce abnormalities of the unborn child or foetus
what is PGE2
prostaglandin- involved in inflammation, mediated by COX-2
what is TXA2
another prostaglandin-like product and is involved in platelet aggregation during clotting, mediated by COX-1
what does ACE stand for
angiotensin converting enzyme
what does ACE do
converts angiotensin I to II
what is ACE inhibitors good as
blood pressure medication
what is statins good as
lowers cholesterol and prevents heart attacks
what is sildenafil (viagra) good for
inhibits the enzyme which breakdown cGMP- helps with erectile dysfunction
what is nevirapine good for
non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 used to treat patients with HIV and AIDs
how does prozac work
an antidepressant that blocks the 5HT reuptake transporter its an SSRI (selective serotonin reuptake inhibitor)
what is serotonin
a neurotransmitter called 5-hydroxytryptamine (5-HT) released from nerve cells in the brain and affects other target nerve cells increasing activity. It interacts with 5-HT receptor on these target cells
salbutamol/adrenaline mechanism of action
interacts with Beta-2-receptor which activates Adenylyl cyclase receptor which increases intracellular cAMP. This inhibits calcium release, decreasing the amount of calcium in cytosol. Which promotes the release of smooth muscle relaxation which widens the airway making it easier to breathe
what are antihistamines
Histamine H1 antagonist
chemical antagonism
one drug antagonises the action of another drug by chemically combining with it
physiological antagonism
2 drugs counteract each other by producing opposing effects on different receptors
why do people have hypersensitivity to pollen
the overabundance of IgE, pollen binds to IgE which then binds to IgE receptors on the surface of mast cells which causes the release of histamine
what cells contain histamine
granules in mast cells
what does histamine cause
inflammation and swelling that leads to hay fever symptoms
what does histamine activating H1 receptor in noses cause
capillary widening- increased blood flow- heat and redness
increased permeability- fluid release into tissue- swelling
attraction of leukocytes- extraversion of leukocytes to site- swelling and tenderness
systematic response- fever and proliferation of leukocytes