Block 6: DKA, Hypoparathyroidism, Hyperparathyroidism, bones Flashcards
Further points for DKA management
- Both the ketonaemia and acidosis should have been resolved within 24 hours. If this hasn’t happened the patient requires senior review from an endocrinologist
- If the above criteria are met and the patient is eating and drinking switch to subcutaneous insulin
- The patient should be reviewed by the diabetes specialist nurse prior to discharge
DKA complications
- Arrhythmias secondary to hyperkalaemia/iatrogenic hypokalaemia
- Iatrogenic due to incorrect fluid therapy: cerebral oedema, hypokalaemia, hypoglycaemia
- Acute respiratory distress syndrome
- Acute kidney injury
- Gastric stasis
- Thromboembolism
- Cerebral oedema
Primary hyperparathyroidism
High Ca+ levels due to high circulating PTH. Causes bone breakdown to release Ca+ and excess reabsorption in the kidney
Symptoms of Hypercalcaemia
- Thirst, polyuria, renal stones
- Weakness, myalgia, bone pain
- Anorexia, vomiting, constipation
- Mood change, depression, confusion
Causes of Hypercalcaemia
- High PTH is primary or Tertiary Hyperparathyroidism, low PTH is cancer or other PTH independent causes
- If cancer its majority Humoral hypercalcaemia and sometimes osteolytic metastasis
Investigations for Hypercalcaemia 1
- Diagnosed by measuring serum adjusted calcium and parathyroid hormone (PTH) levels at same time
- 24-hour urinary calcium to exclude familial hypocalciuric hypercalcaemia where its low
- CT/MRI to identify lesion if suspected
- Estimated glomerular filtration rate (eGFR) and creatinine to assess hydration status, risk of acute kidney injury and presence of chronic kidney disease
Investigations for Hypercalcaemia 2
- Serum and urine protein electrophoresis, including testing for urine Bence-Jones protein to exclude myeloma
- Full blood count (FBC) to exclude haematological malignancy
- Liver function tests (LFTs) to exclude liver metastasis and some systematic diseases
- Dual energy x-ray absorptiometry (DEXA) to assess bone health and risk of osteopenia/osteoporosis
Primary Hyperparathyroidism epidemiology
- More female, peaks 50-70yrs
- Family history
- Benign solitary parathyroid adenoma-85%
- ‘4-gland’ parathyroid hyperplasia-15%
- Parathyroid carcinoma <1%: majority is benign
Inherited forms of primary Hyperparathyroidism- accounts for 15%
- Multiple endocrine neoplasia (MEN)
- Hyperparathyroidism jaw tumour syndrome
- Familial isolated primary hyperparathyroidism
Biochemistry of primary Hyperparathyroidism
- Hypercalcaemia with low serum PO43-
- Raised or high-normal PTH
- Elevated Bony alkaline phosphatase
- Urinary calcium elevated or high normal
Complications of primary Hyperparathyroidism
- Kidney stones, renal impairment
- Osteoporosis at Wrist and Hip
- Osteitis fibrosa cystica: periosteum of fingers and long bones is eroded
- Brown tumours of bone: accumulation of osteoclasts
- Corneal calcification: calcium deposited on the cornea, on the lateral and medial position. Appears white
- ?Hypertension
Management of primary Hyperparathyroidism
- Surgical neck exploration: If patient has symptoms or Complications (renal stones) of hypercalcaemia
- Conservative management with regular monitoring: Only if asymptomatic (majority)
- Calcimimetic drugs (calcium receptor agonists): Cinacalcet, reduces renal stimulation- excrete more in the kidneys
- Bisphosphonates (anti-resorption therapy): Preserve bone density (monotherapy if conservative risk)
Malignant Hypercalcaemia
- Median life expectancy of 6 weeks
- Humoral hypercalcaemia of malignancy (80%): PTHrP related release from tumour- normally released when a baby
- Bone erosion (20%): Diffuse bony disease, Focal osteolytic metastasis
- Rare causes: cancer which release 1,25(OH)2D3 and ectopic PTH
Humoral hypercalcaemia of malignancy (HHM)
- Squamous cell carcinomas: Lung, Breast, Oesophagus, Cervix, Skin, Renal, Bladder, Ovary, Vulva
- Clinically obvious tumour mass
- Excess production of PTHrP from tumour cells which acts on PTH receptors
- Suppressed PTH and 1,25(OH)2D3
- Patients not at high risk of pathological fracture: not one a specific bony lesion that might fracture
Myeloma
- 30% of myeloma patients get hypercalcaemic
- Myeloma sits in bone marrow causes osteolyses by cytokine release
- Diffuse osteolysis due to local cytokines (IL6)
- Causes renal impairement
- Typical biochemical features: Phosphate may be elevated, Alkaline Phosphatase- normal
- Hypercalcaemia is steroid responsive
Hyperparathyroidism: focal osteolytic metastasis
- Lung, breast, prostate
- Direct invasion of the bone by malignancy: seen on plain X-ray
- Local pain
- High risk of pathological fracture
Other causes of Hypercalcaemia
- Drugs (thiazide diuretics, lithium): High PTH
- Vitamin D intoxication: low PTH
- Milk-Alkali Syndrome: increased calcium ingestion and reduced excretion. Normally due to PPI or anti-indigestion meds: low PTH
- Sarcoidosis- increased hydroxylation of vitamin D
- Renal failure: high PTH
- Familial Benign Hypocalciuric Hypercalcaemia: mutation in Ca+2 receptor: High PTH
- Immobility with high bone turnover (astronauts- or teenagers who break their leg): Low PTH
- Endocrine Probs: Hyperthyroidism, Addison’s disease, Phaeochromocytoma
Management of severe hypercalcaemia
- Baseline PTH if first presentation
- Surgery: Parathyroidectomy with primary hyperparathyroidism
- Ca+2 causes nephrogenic DI: Treat dehydration with IV N/Saline (6L/24hrs)
- Specific treatments (next day): IV bisphosphonates (zolendronic acid) if primary hyperparathyroidism. If myeloma give steroids
- Takes 72hrs to normalise calcium:
- SC denosumab if renal impairment
- Calcitonin: reduced calcium concentration by inhibiting kidney and bone reabsorption
- Cinacalcet: reduces serum calcium without affecting bone density or urinary calcium
Parathyroidectomy is indicated:
- Symptomatic disease: Symptoms ofhypercalcaemia, Osteoporosis and/or fragility fractures, Renal stones or nephrocalcinosis
- Age <50 years
- Serum adjusted calcium of 2.85 mmol/L or above
- Estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m
Complications of Hyperparathyroidism
- Osteoporosis and fragility fractures
- Kidney stones and kidney injury
- Hypertension and heart disease
- Numerous gastrointestinal disorders including peptic ulcer disease, pancreatitis and gall stones