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BM212 > Block 4 > Flashcards

Block 4 Flashcards

1
Q

what does hashimotos effect

A

decreases thyroid function, gland is enlarged but insufficient production of hypothyroidism

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2
Q

what is graves disease

A

excessive thyroid function

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3
Q

what does intrinsic factor transport

A

B12

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4
Q

4 different type diseases

A

immediate (I,II,III)
delayed (IV)

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5
Q

what are type II,III induced by

A

antigens that induce IgM and IgG

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6
Q

what is the reaction time for time II,III

A

2-6 hours

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7
Q

What is Type II

A

when antibody reacts with antigen on cell surfaces

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8
Q

What does Type II do

A

damage and death via complement-mediated lysis or antibody-depends cellular cytotoxicity (ADCC)

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9
Q

What is Type III

A

hypersensitivity mediated by immune complexes and resulting complement activation. Complement elicits localised vasodilation and attracts neutrophils

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10
Q

what is Type IV induced by and its reaction time

A

proteins, haptens and 1-2 days

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11
Q

what are Type IV transferred by

A

lymphocytes

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12
Q

what are Type IV effector cells

A

CD4+ T cells, activated macrophages

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13
Q

what are Type IV secreted mediators

A

Cytokines: IFN-gamma, TNF

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14
Q

what is inflammation

A

innate local response to infection or injury

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15
Q

what does inflammation do

A

destroys or inactivates pathogens, clears area of dead cells, and sets stage for tissue repair

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16
Q

cellular components of inflammation

A

neutrophils, macrophages, dendritic cells and mast cells

17
Q

what is inflammation induced and regulated by

A

cytokines

18
Q

what is allergy

A

disease following a response by the immune system to otherwise innocuous antigen

19
Q

what sensitisation

A

involves class switching to IgE production on first contact with an allergen

20
Q

what is HIV

A

retrovirus that establishes a chronic infection that slowly progresses to AIDS

21
Q

what co-receptor deficiency confers resistance to HIV infection

A

CCR5

BM212 (4 decks)

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