Block 2 Lecture 6 -- ASDs Part 2

Question 1

Tiagabine MoA

Answer 1

GAT-1 inhibitor

Question 2

Tiagabine indication

Answer 2

focal (mainly adjunct)

Question 3

Where are GABA Reuptake Transporters located?

Answer 3

presynaptic and astrocytic membranes

Question 4

Vigabatrin MoA

Answer 4

GABA-TA inhibitor

Question 5

Vigabatrin indication

Answer 5

1) refractory complex focal
2) West
3) adjunct for infantile spams

Question 6

What is West syndrome?

Answer 6

spasms beginning between 3-5 mos; non-treatable

– mental retardation

Question 7

Phenobarb MoA:

Answer 7

binds barb site of GABAa to prolong opening of Cl chanel

Question 8

Phenobarb indication

Answer 8

all seizure types except absence

Question 9

BZD indication

Answer 9

all including status epilepticus

Question 10

What BZDs are used for epilepsy?

Answer 10

1) diazepam
2) clonazepam
3) lorazepam
4) chlorazepate
5) clobazam

Question 11

Where is diazepam mainly used?

Answer 11

SE

Question 12

Where is clonazepam mainly used?

Answer 12

long-term (also absence)

Question 13

Where is lorazepam mainly used?

Answer 13

SE

Question 14

Where is chlorazepate mainly used?

Answer 14

in long-term

Question 15

Where is clobazam mainly used?

Answer 15

adjunct for Lennox-Gastaut syndrome