Block 13 Flashcards
Evidence based decision is based on…
Clinical expertise
Research
Patient preference
Available resources
What is decision analysis?
Decision analysis is a systematic, explicit, quantitative way of make decisions in health care that can lead to both enhanced communication about clinical controversies and better decisions
Normative decision making
What we should do
Decriptive decision making
What we are doing
Prescriptive decision making
How we can improve
Decision analysis is based on
Based on a normative theory of decision making: subjective expected utility theory (SEUT)
Normative =
Based on social norms, shared interpretations/understanding
Subjective =
Subject to interpretation
Expected =
Future events
Utility =
desirability or value attaches to a decision outcome
Evidence in decision trees come from
- Probabilities
2. Utility or cost associated
Info in decision tree should come from
Good quality research/best available evidence
5 stages of decision analysis:
- Structure into decision tree
- Assign probability
- Assign utility
- Calculate value
- Sensitivity analysis
Square node =
Decision node, choice between actions
Circle node =
Chance node/uncertainty or potential outcome
Each branch is decision tree must =
100%
1
Ways to assess utility
Utility measures
QALYs
VAS
Name a utility measure
EQ-5D
EQ-5D
People with a particular health state fill in questionnaire
5 domains of EQ-5D:
- Mobility
- Independence
- ADLS
- Pain, discomfot
- Worried/sad/happy
VAS =
Visual analogue scale
QALY =
Quality adjusted life year
Health states can be measured against what?
QALYs
Value of each branch =
utility x probability
In a decision tree sensitivity analysis, a decision can be:
- Preference sensitive
2. Probability sensitive
Benefits of DA
- Makes all assumptions in a decision explicit
- Allows examination of the process of making a decision
- Integrates research evidence into the decision process
- Gain insight during process
- Can be used for: individual, population level, cost-effectiveness analysis
Limitations of probability estimates in DA
- Required data dets of estimate probability may not exist
- Subjective probability estimates are subject to bias
Limitations of utility measures in DA
- Individuals may be asked to rate a state of health they haven’t experienced
- Different techniques = different numbers
- Subject to presentation framing effects (e.g. survival/death)
- Reductionist – e.g. ‘affected’ vs ‘unaffected’ reduces a complex issue into 2 options.
Colin Murray Parkes states the
4 stages of grief
4 stages of grief (Colin Murray Parkes)
- Numbness
- Yearning/pining and anger
- Disorganised and despair
- Reorganisation
Who decribed some of the symptomology of acute grief?
Lindemann
Lindemann acute grief:
- Somatic/bodily distress
- Preoccupation with the image of the deceased
- Guilt re: the deceased or circumstances of death
- Hostile reactions
- Inability to function as one has before the loss
- Development of traits of the deceased in their own behaviour
Grief symptomology can be split into what domains?
Emotional
Somatic
Cognitive
Depression-like
Emotional symptoms of grief:
Sadness Anger Guilt Anxiety Loneliness Helplessness Shock Yearning Numbness
Somatic symptoms of grief:
Sensations from stomach, chest, throat Sensitivity to noise Breathlessness Weakness Lack of energy
Cognitive symptoms of grief:
Disbelief
Preoccupation
Sense of presence
Hallucination
Who described the tasks of mourning?
Worden
What did worden believe grief was?
An active process
Tasks of mourning:
- Accept the reality of loss
- Work through the pain of grief
- Adjust to an environment in which the deceased is missing
- Emotionally relocate the deceased and move on with life
Pathological grief is grief which is
Extended (>6 months)
What can happen in complicated grief?
Mummification
denial
Mummification -
Preserving aspects of the deceased’s life pathologically
Impact of close death:
Loss of presence (function, emotional, role in life)
May change persons role
Forced to confront own mortality
Traumatic undermining of world view
What effects grief severity?
- Closeness of relationships, meaningfulness of relationship, nature of relationship.
- Expectedness and manner of death
- Age and developmental stage of griever
- Individual resilience: neuroticism, introversion, childhood trauma, parenting, attachment and dependency
- Religious belief
- Social support
Which attachment style might lead to complex grief?
Dependent
Impact of religious belief of bereavement:
- Belief in afterlife: continuing existence of the loved one and possibility of meeting up again, continued attachment (prayer means of continuing connection).
- Defence against fear of personal death/extinction
- Religious funeral rituals aid and progress the grief response
- Religious funeral rituals that recruit social support
Palliative care =
The active, hollistic care of patients with advances, life-limiting, progressive illness
Palliative care aims to =
Improve QOL: pain, other symptoms, psychologial, social, spiritual support
2 types of palliative care services:
- General
2. Specialist
General palliative care is done by
All health professionals: Primary health team Nursing home Secondary care Social services
What is included in general palliative care?
- Holistic needs assessment
- Provision of basic symptom control
- Referral if needed
Supportive care =
Happens before diagnosis, after diagnosis, during treatment, palliative care, bereavement
Terminal care =
Treatment, care and support for people nearing end of life
When is specialist palliative care provided?
• Patients and carers with unresolved symptoms and complex psychosocial issues with complex end-of-life and bereavement issues
What does complex mean in the context of palliative care?
Cannot be dealt with by general professionals
Who provides specialist care?
Specialist nurses
Specialist consultants
Hospice
Chaplain etc.
Where does the funding for palliative care come from
NHS
Voluntary and charity sector
What does the NHS provide for PC?
- Doctors, nurses
- Some in patient beds
- Community clinical nurse specialist
Macmillian funding =
Part NHS
Part charity
What does the voluntary sector provide for PC?
Hospice
most inpatient beds
Marie curie nurses, macmillian nurses
District nurse =
Based in community
Generalist
Hands on
Practice nurse =
Based in practice
Generalist
Hands on
Marie curie nurse =
Community
Specialist
Hands on
Macmillian nurse
Community or hospital
Specialist
Advice, support, resource
Most people would prefer to die where
At home
Challenges for the future of PC:
- How do we maintain sense of humanity and compassion
- Attitude to death as not being a medical failure
- Inequality between cancer and other probelms for referal
- Recruitment and training
Highest cause of world-wide mortality:
Cardiovascular disease
What % of all CVD deaths are in low and middle income countries
75%
What % of deaths is attributable to CVD
30%
CVD rates change in one country depending on
Social gradient/socioeconomic status
Ethnicity with highest levels of CVD
Bangladeshi men
Pakistani men
Ethnicity with lower levels of CVD
Carribean
West africa
What might higher rates of CVD in Bangladeshi men be linked to?
Higher rates of smoking
What experience is important for CVD
Experiences in early life
Non-modifiable RF for CVD
Age Male FHx ACE mutation Social deprivation
Modifiable RF for CVD
Hyperlipidemia Hyperchlesterolemia Hypertension Smoking Diabetes Lack of exercise Coagulation factors Homocyteinaemia Obesity Gout Drugs
Most important/RF which are targets in CVD
Hypercholesterolemia
Smoking
Hypertension
Risk =
Probability of an event occuring in a given time period
Risk ratio =
The ratio of the probability of an outcome in an exposed group to the probability of an outcome in an unexposed group.
Risk ratio is the same as
Relative risk
ABCD method of calculating risk what is RR
a/(a+b) / c/(c+d)
Odds ratio
Odds that an outcome will occur given a particular exposure, compared to the odds of the outcome occurring in the absence of that exposure.
ABCD method, what is OR?
ad / bc
Risk difference is the same as
Attributable risk
Risk difference equation
Risk in exposed - risk in unexposed
Why is size not everything in risk?
Small risk from a common exposure may have a big impact
What is a better measure of the impact of an exposure on a population?
Risk difference
What is used in epidemiology to measure and assess the public health impact of exposures in populations.
Population attributable risk
Population attibutable risk =
The fraction of all cases of a particular disease/adverse condition in a population that is attributable to a specific exposure.
PAR depends on
Prevalence of exposure
RR/relationship between risk and exposure
PAR is higher with
Higher prevalence of exposure
Higher RR
What is the prevention paradox
A preventative measure that brings large benefits to the community offers little to each participating individual.
Most CVD occur in people at what risk?
Low/moderate
2 strategies to reducing risk:
High risk strategy
Population strategy
Which strategy is needed to have a large effect?
Population strategy
Benefits of high risk strategy
- Appropriate to individual
- Motivated subject
- Motivated clinician
- Cost-effective resource use
Cons of high risk strategy
- Screening difficult
- Palliative and temporary
- Limited potential
- Labelling
Pros of population strategy
large potential
Cons of population strategy
- Population paradox – small individual benefit
- Poor motivation
- Benefit:Risk (LOW)