Block 1 Flashcards
What transports T3 or T4 into the follicular cell?
MCT8(10)
How does insulin secretion happen?
Extracellular glucose is transported into the β -cell via GLUT-2.
Glucose is metabolised which increases adenosine triphosphate to diphosphate (ATP:ADP) ratio within the cell.
This leads to closure of ATP-dependent K+ channels
Closure of K+ channels leads to cell membrane depolarisation
Membrane depolarisation leads to opening of voltage dependent Ca2+ channels and Ca2+ influx
Ca2+ influx leads to exocytosis of stored insulin vesicles
Where is GLUT1 found?
red blood cells and blood brain barrier
Where is GLUT2 found?
β -cells and liver
Where is GLUT3 found?
placenta and neurons
Where is GLUT4 found?
adipocytes and muscles
Where is GLUT5 found?
Enterocyte uptake from gut lumen
Which GLUT transporter provides the insulin-dependent response?
GLUT4
Which GLUT transporters allow movement at low (basal) glucose levels?
GLUT 1,3 and 4
