blistering disorders Flashcards
what is nikolsky’s sign?
top layers of skin slip away from lowers when rubbed
what is the management of blistering disorders?
suppress immune system (steroids)
what layer of skin does pemphigus vulgaris affect?
superficial
how does pemphigus vulgaris occur?
IgG attack desmosomes attachments -> acantholysis
inta-epidermal - mucosal involvement
Nikolsky positive
what is a buzz word phrase for pemphigus vulgaris?
thin roof blisters
what layer of skin does bullous pemphigoid affect?
deep
how does bullous pemphigoid typically present?
elderly patients
localised to one area
Nikolsky negative
deep blisters, very itchy
what is dermatitis herpetiformis?
autoimmune condition associated with coeliac and thyroid disease
how does dermatitis herpetiformis typically present?
very itchy erosions from scratched vesicles
similar distribution to psoriasis
