Blistering disorders

Question 1

What are the intradermal immune blistering disorders?

Answer 1

Pemphigus vulgaris
Pemphigus foliaceus
Ig A pemphigus
Paraneoplastic pemphigus

Question 2

Clinical manifestations of pemphigus vulgaris

Answer 2

Flaccid blisters on normal appearing skin, that rupture easily and are not pruritic. Palms and soles are usually spared. Nicholsky sign is present.
Mucosal involvement is common, particularly oral lesion. Mucosal lesions are very painful and as the blisters erode easily, erosions are more commonly seen

Question 3

Pemphigus vegetans: clinical presentation

Answer 3

A form of pemphigus vulgaris composed of vegetating plaques with excesive granulation tissue and crusting particularly in intertriginous ares, scalp and face.

Question 4

Pemphigus herpetiformis: clinical presentation

Answer 4

A form of pemphigus vulgaris that manifests with urticarial plaques and cutaneous vesicles arranged in a herpetiform or annular pattern

Question 5

Pemphigus foliaceus: clinical presentation

Answer 5

Superficial variant of pemphigus usually developing in seborrheic distribution with small, scattered superficial blisters that rapidly evolve into scaly, crusted erosions with positive Nicholsky sign

Question 6

IgA pemphigus: clinical presentation

Answer 6

There are two varieties subcorneal pustular dermatosis and intraepidermal neutrophilic dermatoses. They course with vesicles that evolve into pustules predominantly in the trunk. Mucous membranes are usually spared