Bleeding Disorders

Question 1

Replacement for hemophilia A and B

Answer 1

A 50u/kg q8-12h
B 100u/kg q12-24

Question 2

Risk of inhibitor development in hemophilia

Answer 2

• A more than B
• common within weeks of first factor administration

Question 3

What defines hemophiliacs that would benefit from ppx

Answer 3

1 - severe
2 - mild to mod with increased bleed hx

Question 4

Define levels of hemophilia

Answer 4

Mild 5-30
Moderate 1-5
Severe <1

Question 5

VWF treatment Peripartum

Answer 5

• keep level >50 x3-5 days
• TXA 25mg/kg q8 x 2 weeks