Bleeding Disorders Flashcards
Primary haemostatic response:
platelet plug formation
platelets, vWF, wall
secondary haemostatic response:
fibrin plug formation
what is haemorrhagic diathesis?
a tendency to bleed or bruise easily
inhibition of function
- platelets
- vWF
- coagulation factors
who usually gets haemophilia?
males
what factor deficiency contributes to haemophilia A?
Factor VIII
what factor deficiency contributes to haemophilia B?
factor IX
what are the risk factors for congenital haemophilia?
FH of haemophilia
Male sex
what are the risk factors of acquired haemophilia?
Age over 60
autoimmune disorders, IBD, diabetes etc
what are signs and symptoms of haemophilia?
fatigue
bruises
menorrhagia
cutaneous purpura
Clinical complications of haemophilia
synovitis
chronic haemophilic arthroplasty
neurovascular compression
haemophilia treatment of bleeding diathesis
coagulation factor (VIII, IX) replacement
Transexamic acid
prophylaxis
haemophilia treatment
splints
analgesia
physio
synovectomy
von Willebrand disease - how common is it?
1 in 100
what type of bleeding occurs in Von Willebrand disease?
platelet type bleeding (mucosal)
type 1 von willebrand is what kind of deficiency?
quantitative
