Bladder Disorders and Urinary Incontinence Flashcards
Hematuria:
- signs of glomerular bleeding
- what does the work up include?
Glomerlar bleeding signs:
- red cell casts
- dysmorphic RBC
- hematuria with proteinuria w/ a large % being albumin.
Work up: -Clean catch urine culture -urine cytology -CT urography* -US in pregos -cystoscopy (cystoscopy and CT urography are always done together)
Cystitis:
- pathogenesis
- MC pathogen
- presentation
- dx
- Tx for men and women
Pathogenesis:
-colonization of the vaginal introitus from fecal flora, ascension to the bladder via the urethra. if this ascends to the kidneys it becomes pyelonephritis
MC is e. Coli , others may include proteus and klebsiella
Presentation:
- dysuria
- frequency
- urgency
- suprapubic pain
- hematuria
- pyuria
Dx:
- UA***** (will see + leukocyte esterase/ +nitrites)
- ALL males should have a culture.
Tx: Women: -Nitrofurantoin -Bactrim -Fosfomycin -reserve FQ for severe cases such as pyelonephritis -phenozopyridine(anesthetic) MEN: -Bactrim -FQ
Pyelonephritis:
- pathogenesis?
- sx
- dx
- tx
pathogenesis: cystitis gone wrong.
Sx: chills, flank pain w/ CVA tenderness, nausea, vomiting
Dx:
- UA
- Urine culture and sensitivities
Tx:
Outpatient: FQ (Cipro or levo)** may also use bactrim or augmentin but not used often.
Inpatient: PO FQ + Aminoglycoside
Noninfectious Cystitis:
- sx
- cause
- work up
- tx
Sx: -dysuria
- frequency
- urgency
- suprapubic pain
- hematuria
- nocturia
- pressure in pelvis
Cause:
-bubble baths, feminine hygiene sprays, tampons, radiation, chemo, tomatoes, artificial sweeteners, caffeine and chocolate.
Work up:
- UA
- UC
- Sometimes cystoscopy
Tx:
- avoid irritants
- voiding routine*
- Kegels
Nongonococcal Urethritis in males:
- cause
- Manifestations
- dx
- tx
Cause: chlamydia
Manifestations:
- urethritis:asymptomatic/ symptomatic
- epididymitis: swollen, red, hot testicle
- prostatitis
Dx: NAAT testing
Tx:
rocephin and azithromycin
Gonorrhea in Males:
- manifestations
- dx
- tx
Manifestations:
- urethritis: symptomatic
- epididymitis: less than 35YO
Dx: NAAT
Tx:
- Rocephin and Azithro
- make sure to treat the partner, no sex until infection cleared, educate on safe sex, test for HIV
Overactive Bladder:
- pathophys
- presentation
- SE of medications used for tx
- MOA of medications
- tx
Pathophys: detrusor muscle contracts before bladder is filled. (irregularly at smaller volumes of urine)
-may be 2ndry to DM, stroke, spinal dz
Presentation:
- urgency
- frequency
- nocturia
SE:
-anticholinergic SE, dry mouth, constipation, blurred visiion
MOA:
-increase bladder capacity
-block basal release of ach during bladder filling
(relaxes detrusor muscle so it doesnt spams)
Tx:
- antimuscarinics such as:
- -oxybutynin (Ditropan)
- -Tolterodine (Detrol)
- -Solifenacin (Vesicare)
- Mirabegron (Mybetriq)
- SE is HTN, dry mouth, incomplete bladder emptying.
Urinary Incontinence:
-related causes of morbidity
Morbidity:
- perineal candida infection
- cellulitis/pressure ulcers
- UTI/Urospesis
- Falls/Fxs
- sleep deprivation
- psychological: poor self esteem, social withdrawal, depression, sexual dysfunction
Incontinence:
-causes
Causes: DIAPPERS -Delirium -Infection -Atrophic Vaginitis -Pharmacologic; sedatives, diuretics, anticholinergics -Psychological: depression -Excessive urine production -Restricted mobility -Stool impaction
Urge Incontinence:
- etiology
- presentation
etiology:
- uninhibited bladder contractions
- detrusor over activity
- bladder abnormalities or idiopathic
Presentation:
-sudden urge to void preceded or accompanied by leakage of urine
Stress incontinence:
-etiology
Etiology: leakage of urine with increased intra-abdominal pressure in the absence of bladder contraction (such as coughing/sneezing)
- may be d/t urethral hypermobility or intrinsic sphincter deficiency
- prostate surgery MC in men
Mixed Incontinence:
-what two types of incontinence?
What is the MC type of incontinence in women?
Mixed incontinence is urge &/or stress leakage.
MC type of incontinence in women is mixed.
Overflow incontnence:
- aka
- what is this?
- cause
aka: incomplete emptying
What is this: continuous leakage or dribbling of urine
cause:
- detruser underactivity:
- -low estrogen
- -aging
- -peripheral neuropathy
- -damage to spinal detrusor efferents (MS)
- -bladder outlet obstruction (BPH)
Nocturia:
-causes
Causes:
- CHF
- late evening beverages
- sleep apnea**
- sleep disturbances (chronic pain, depression)
- detrusor overactivity
Incontinence:
-dx tools
Dx:
-bladder diary (record time and volume of every incontinent and continent void over 42-78hrs, include activity, caffeine, sleep)
- CV, Resp, Neuro, genital, prostate exams.
- Post void residual (PVR less than 1/3 total voided volume is considered adequate voding)
- Labs: renal function, serum calcium and glucose, UA, PSA for men, B12, urine cytology if hematuria or pelvic pain