Bipolar Disorders Flashcards
What is the difference b/w Bipolar I and Bipolar II
The severity of mania
What drug class is used to treat Bipolar disorder
Mood Stabilizers
Mood Stabilizers agents
Lithium (Lithobid)
Valproate
Lamotrigine
Carbamazepine
Which mood state do Bipolar patients cycle between
Depression and Mania
When are antipsychotics used in Bipolar patients
Which antipsychotics are used
When patients also suffer from psychosis
Second gens are preferred over first due to EPS risk
Note: Some second gens antipsychotic drugs also have antidepressant effects
Are antidepressants recommended in Bipolar patients? Why or Why not
NO
b/c they can induce manic episodes
They are only used if patient is already on a mood stabilizer
What is the first line therapy for a Manic state in Bipolar patients
Valproate or Lithium
+
an antipsychotic
What is the first line therapy for acute Bipolar depression
Lithium
or
Lamotrigine
What is Lamotrigine used for in Bipolar patients?
Bipolar Depression maintenance
What is Valproate (and less commonly Carbamazepine) used for in Bipolar patients?
Bipolar Mania as mood stabilizers
What is Lithium used for in Bipolar patients?
Mania
Bipolar depression
Maintenance
What drug is safest to use in Pregnancy when treating Bipolar disorder?
Lamotrigine for a mood stabilizer
and
Lurasidone for bipolar depression
What is the therapeutic range for Lithium
0.6-1.2 mEq/L (trough level)
Lithium ADE
Cogwheel rigidity GI upset (Nausea, anorexia, abdominal pain) Cognitive effects Tremor Weight gain Polyuria/polydipsia Hypothyroidism
Lithium counseling points to minimize ADE
Titrate slowly Shift dose to QHS Take dose at the end of a meal Drink adequate fluids Don't change your salt consumption
