Bipolar disorder Flashcards

1
Q

What is Disruptive Mood dysregulation?

A

Recurrent temper outbursts in response to common stressors

  • begins at age 10
  • at least 3 per week
  • occurs in at least 2 settings
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2
Q

What are some examples of emotional regulation?

A
  • reactive attachement disorder
  • infants of depresses mothers
  • fetal alcohol spectrum disorder
  • PTSD
  • Personality disorders
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3
Q

What are the genetic states behind bipolar 1 disorder?

A

50-80% twin-twin

- up to 85% heritability

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4
Q

What are some neurophysiologic characteristics of bipolar disorder?

A

Limbic hyperactivity

  • deactivation in the inferior frontal cortex or ventrolateral prefrontal cortex
  • not in euthymic and depressed states
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5
Q

what are the 2 hypothesis’ fro monoamine hypothesis?

A
  • Monoamine hypothesis

- Neurotransmitter receptor hypothesis

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6
Q

What is the suicide rate for bipolar disorder and MD?

A

> 10% and

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7
Q

What is axis I and axis II?

A

Mood, attn, and substance abuse for I

- 2= personality disorders

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8
Q

What are the only 2 drugs that have shown to demonstrate reduction in suicidal thoughts?

A

Lithium carbonate and clozapine?

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9
Q

What are some of the side effects of depkote?

A

Hepatotoxicity and thrombocytopenia

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10
Q

What should one monitor for a pt on Tegretol?

A

Agranulocytosis

hepatotoxicity

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11
Q

What are some atypical antipsychotics? AKA neuroleptics

A
risperidone (Risperdal)
olanzapine (Zyprexa)
quetiapine (Seroquel)
ziprasidone (Geodon)
aripiprazole (Abilify)
asenapine (Saphris)
iloperidone (Fanapt)
Haloperidol (Haldol)
Fluphenazine (Prolixin)
Thioridazine (Mellaril)
Chlorpromazine (Thorazine)
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12
Q

What is neuroleptic malignant syndrome?

A

Potentially fatal condition with loss of body temp regulation, renal and respiratory failure, ANS impairment and LOC

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13
Q

What is the treatment for acute mania?

A

Lithium, Valproic acid and carbamazepine

  • 2nd line neuroleptics
  • ECT
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14
Q

What is the treatment for acute/chronic depression?

A
  • Stage 1 is lamotrigine (Lamictal) +/- mood stabilizer or neuroleptic
  • Stage 2 is quetiapine (Seroquel) or olanzapine (Zyprexa) + fluoxetine (Prozac) combination
  • Later stages involve other antidepressants + an antimanic agent
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