bipolar disorder Flashcards
what are the symptoms of mania
At least one week of persistently euphoric, expansive or irritable mood P
lus at least three or more of:
• Inflated self esteem / grandiosity
• Decreased need for sleep
• More talkative than usual, pressure of speech
• Flight of ideas, thoughts racing
• Distractibility
• Increased goal-directed activity
• Excessive involvement in pleasurable activities that may have high potential for painful consequences
Must lead to marked impairment or psychosis
how long is hypomania for
(Hypomania >4 days; no impairment)
more than 4 days
what does mania require to be a clinical problem
‘Mania’ requires:
– Euphoric or irritable mood plus 3 of the others
– One week or more of symptoms
– Marked impairment, hospitalisation or psychosis
what does hypomania require to be a clinical problem
– Euphoric or irritable mood plus 3 of the others
– 4 or more days of symptoms
– No necessary impairment but not ‘normal self’
what is unipolar depression
at least one episode of depression in their lifetime
neve had hypomania or mania
bipolar 1
at least one episode of mania and one episode of depression
bipolar 2
at least one episode of depression and one of hypomania
bipolar 1 - unipolar mania
at least one episode of mania
what are the associated symptoms of mania
- Symptoms during mania also include dysphoria, anxiety, panic and aggression (e.g Cassidy et al., 1998)
• Symptoms of depression typical even during remission (Judd et al., 2002)
• High levels (>50%) of comorbid disorders: anxiety, personality, substance abuse
• Studies show 2x UP rate of certain anxiety disorders (OCD – Chen & Dilsaver, 1995; panic & GAD – Simon et
al., 2003)
what are the biological factors of mania
Heritability high – (Kieseppa et al., 2004)
more likely to have it if have first degree relative who has it
• Separate heritability of mania & depression (McGuffin et al., 2003)
• Genes for mania may involve reward pathways, i.e. dopamine function
highs - reward pathwasy
lows- neuroticism
‘resistance’ to bipolar disorder
High levels of functioning
– Lower levels of catastrophising about changes in internal states
– Reported ‘awareness’ of behaviour and social impact when feeling high
what are the predictors of relapse
- Stressful interpersonal life events (Hammen et al., 1992) M&D
- High ‘Expressed Emotion’ (hostility, overprotectiveness, criticism) in family members (Miklowitz et al., 1988) M&D
- Disrupted social rhythm events (Malkoff-Schwartz et al., 1998) – Mania not D - going outside normal sleep wake patterns
- Goal-attainment Events (Johnson et al., 2000) – Manic symptoms not D - achievingthings
important issues predicting relapse in bipolar
- Poor compliance with medication – normative; often ineffective; side effects
- Poor acceptance of ‘illness’ - normative
- Poor recognition; delays in diagnosis
- Ambivalent views of hypomanic symptoms
- Stigmatisation
- Stress on family members
- Interpersonal processes during therapy - therapists have to be malleable to change in mood
what is the treatment for BP - medication
• Medication
– Typically mood stabilisers (e.g. lithium) but also anti- depressants, ant-psychotics and anxiolytics
– large majority of treated people with BP
– high relapse rates despite adequate medication (Solomon et al., 1995) – c.60% in 2 years
what is the psychological treatment for BP
Psychological Treatments (usually in addition to med):
– Relapse prevention or psychoeducation – effective (Colom et al., 2003; Perry et al., 1999)
– Family Focused Therapy (Miklowitz et al., 1988)
– Cognitive Behavioural Therapy (Lam et al., 2003)