alcohol and substance use disorders Flashcards

1
Q

what do we mean by substance use

A

drugs
alcohol
misuse of prescribed medication
use of other legal substances for purposes ‘not consistent with legal or medical guidelines’

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2
Q

what is the DSM criteria for substance abuse disorder

A

• SUD criteria not to do with frequency / dose

– diagnosis relects the IMPACT of substance use on funcioning in every day life: the harm that is being done

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3
Q

what are the consequences of substance use on physical health

A

•Physical Health
–Direct: Liver, heart & lung damage, increased cancer risk
•New alcohol guidelines based on evidence that the risk of cancers, especially breast cancer increases directly in-line with consumpion of alcohol.

–Indirect: illness, injury, self neglect, harm from risky behaviours (hepaiis, HIV, overdose) - e.g. sexual activity, drive under the influence

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4
Q

what are the consequences of substance use on finance

A

–Cost of drug and alcohol use; lost income due to intoxicaion and after-efects (hangovers)

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5
Q

what are the consequences of substance use on social and interpersonal relationships

A
–Conlict with others (e.g. disapproving family members)
–Exclusion / sigma
–Poor educaional atainment
–Homelessness
--family breakdown
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6
Q

what are the consequences of substance use on mental health

A

– Transient psychosis (e.g. cannabis induced psychosis)
– Depression & Anxiety (e.g. depressant efects of alcohol)
– For people with established illness (e.g. psychosis)
• More / worse symptoms
• Poorer funcioning
• More relapses and hospitalisaions
• Increased suicidality; Aggression

– In 2019/20 there were 7,027 hospital admissions with a primary
diagnosis of drug-related mental health and behavioural disorders (135
people per week) - 21% higher that 2009-10 (but down slightly from the
previous year).

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7
Q

what are the consequences of substance use as a societal and economic burden

A

– Rising NHS costs & welfare costs. 358,000 admissions to hospital in 2018/19 where the main reason was due todrinking alcohol (almost 1,000 people per day) - 6% higher than 2017/18 and 19% higher than 2008/09

– Criminal acivity (e.g. public order ofences)

– Increased rates of mental health problems (e.g. psychosis)
due to substance use?

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8
Q

how common is SUD

A
  • Esimates vary between sengs and geographical locaion (e.g. London versus Rural Wales)
  • Comparisons hampered by methodological diferences (study design; sample; how substance use deined)
  • UK: Not known how many people with SUD diagnosis
  • AUD esimate = approx. 600,000 (1%)
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9
Q

what effects SUD in geographical locations

A

Availability social factors playing into the demographics of a neighbourhood e.g. whether drugs are available whether an area is more deprived or not whether its made up of old or young people
Hard to get an idea of what’s going on in the uk more generally

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10
Q

what is the prevalence of drugs in UK

A

2020 England and Wales Crime Survey (conidenial):
•35% of adults aged 16 to 59 had taken drugs at some point during their lifetime.

•1 in 11 (9%) adults aged 16 to 59 had taken an illicit drug in the last year (3.2 million
people).

•1 in 5 (21%) young adults aged 16 to 24 had taken an illicit drug in the last year;
4.3% classed as ‘frequent” drug users (at least monthly use)

•Drug use fell 1995-2013 but is now rising again, with a large porion of the increase
resuling from increased use of class A drugs in 16-24 year olds (largely
MDMA/ecstasy and powdered cocaine)

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11
Q

what is the prevalence of alcohol use in UK

A

–65% of men and 50% of women had drunk alcohol in past week
–Prevalence increases with age (up to 75)

–38% of men and 19% of women aged 55-64 drinking ‘above safe
limits’ (14 units +)

–More people ‘never’ drinking increasing and binge drinking decreasing, paricularly among young adults

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12
Q

why is there a difference in prevalence

A

• Some groups more likely to drink problemaically / use illicit substances than
others (young people, especially students;
people with mental health problems)
– Drug-related hospital admissions are ive imes
more likely in the most deprived areas.

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13
Q

does diversity effect substance use

A

yes religious and cultural background

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14
Q

what is comorbidity

A

Comorbidity: When two disorders or illnesses occur simultaneously in the same person

– Substance use and mental health problems are highly comorbid (occur frequently together)

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15
Q

what is dual diagnosis

A

Dual diagnosis: term used to describe people with both severe mental illness (mainly psychoic disorders) and problemaic drug and/or alcohol use - “Dually diagnosed”

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16
Q

what are the comorbidity rates

A

• Epidemiological studies consistently report higher rates of substance use (lifeime & current) in psychosis samples than general populaion (UK and elsewhere)

17
Q

why are rates of substance use higher in those with psychosis

A

Why psychosis?
• Rates of substance use (drugs, alcohol and tobacco) significantly higher in people with psychosis
– 50% of people with psychosis use substances; 85% smoke cigarettes

• Poorer outcomes for substance users with psychosis
– More symptoms; more relapses & hospitalisaions; poorer functioning and increased suicidality

• Possible causal role of substances in development of psychosis/ schizophrenia (cannabis)

18
Q

why not bipolar

A

• Psychosis more common than bipolar disorder in the UK
• Larger evidence base regarding substance use and psychosis
- possible causal relaionship between psychosis and cannabis

19
Q

what is psychosis

A

• Psychosis : a loss of contact with reality that usually includes:
– False beliefs about what is taking place or who one is (delusions)
– Seeing or hearing things that aren’t there (hallucinaions)

20
Q

what is schizophrenia

A

• Schizophrenia (Sz): Two of: delusions; hallucinaions; disorganised speech; disorganised or catatonic behaviour with negaive symptoms; with social/occupaional dysfuncion, lasting 6+ months

21
Q

what are the causes of comorbidity

A
  1. Substance use causes psychosis
  2. Substance use a consequence of psychosis (self-medicaion)
  3. Common origin (e.g. geneic vulnerability)
  4. Bidirecional – psychosis and substance use interact and maintain one another
22
Q

what is the evidence that some substances cause transient psychosis (suggesing that the 1st causal hypothesis is plausible)

A

• Amphetamine, cocaine and cannabis -induced psychosis
• Experimental work with the main psychoacive ingredient of cannabis
- tetrahydrocannabinol (THC) e.g. D’Souza et al (2004;2005)

– THC produces schizophrenia-like posiive symptoms in healthy individuals
– THC transiently increases symptoms in people with schizophrenia
– People with schizophrenia are more vulnerable to the efects of THC

23
Q

what is the evidence that some substances cause transient psychosis

A

Evidence that substance use (cannabis) oten precedes psychoic symptoms from longitudinal prospecive cohort studies

50+ uses of cannabis use pre 18 meant a 6x greater
likelihood of hospitalisaion for Schizophrenia at age 33

24
Q

what is the evidence that substances are used as self-medication in psychosis

A

evidence that people with psychosis report using substances to self-medicate
coping mechanism
use for same reason as everyone else

25
Q

what is the evidence that theres genetic vulnerability

A

Evidence that geneic factors may predispose individuals to both mental illness and substance use (e.g. Estrada et al (2011) – DUNEDIN cohort study)

– Adolescents with COMT polymorphism (Val allele) 10x more likely to have schizophreniform disorder at age 26

• Substance use may precipitate psychosis i.e. may causepsychosis in people who would have developed it anyway (more suscepible to psychotogenic efects)

26
Q

are substance use and psychosis highly comorbid

A

• Substance use and psychosis highly comorbid, occurring together more oten than by chance

27
Q

what causes transient psychosis

A

• Some substances cause transient psychosis
• Evidence of geneic vulnerability in some
• Some people use substances to lessen symptoms (self-medicate)
– Substance use typically precedes psychosis
– Link between cannabis and psychosis biologically plausible

28
Q

does substance use cause psychosis

A
  • Simple causal models too simplisic
  • Most likely explanaion is that the relationship is bidirecional with muliple risk factors (geneic, environmental, individual diferences) playing a part
29
Q

what are the risk factors of substance use

A
availability
stress (family conflict)
trauma (abuse)
social networks
coping
30
Q

SUD definition - the DSM 5 focus on impact rather than amount / frequency

A

SUD definition - the DSM 5 focus on impact rather than amount / frequency