Bipolar and pharm

Question 1

Bipolar I

Answer 1

Hx of at least one manic episode, with or without past major depressive episode.

Question 2

Bipolar II

Answer 2

History of at least one episode of major depression and at least one hypomanic episode.
NO hx of manic episode

Question 3

Manic episode

Answer 3

A distinct period of abnormally and persistently elevated mood lasting at east 1 wk.
Significant impairment
Often leads to arrest, hospitalization

Question 4

Bipolar is genetic.

Answer 4

Believe it.

Question 5

Rapid cycler

Answer 5

At least 4 mood changes in one year.

Question 6

Bipolar II has greater risk of?

Answer 6

Attempting and completing suicide.
Marital discord
Generalized depression

Question 7

Cyclothymia

Answer 7

Hypomanic and depression symptoms, frequently switching.

Depression is not major

Question 8

Lithium

Answer 8

Significantly decreases frequency and severity of both manic and depressive episodes in about 70% of pts.

Question 9

Lithium SE

Answer 9

Low therapeutic index
Polydipsia, polyuria
Edema, weight gain
Thyrotoxic
Tremor

Question 10

Valproate Brand name

Answer 10

Depakote

Question 11

Valproate

Answer 11

Becoming recognizes as first line.
Less SE
Quick onset

Question 12

Valproate SE

Answer 12

Weight gain
N/V
Hair loss
Tremor
Liver failure
Thrombocytopenia
Pancreatitis

Question 13

Carbazepine brand name

Answer 13

Tegretol

Question 14

Tegretol

Answer 14

Comparable efficacy to lithium

Question 15

Tegretol SE

Answer 15

N/V
Hyponatremia
Rash (SJ)
Drowsiness, blurred vision
Blood dyscrasias

Question 16

Lamotrigine brand name

Answer 16

Lamictal

Question 17

Lamictal

Answer 17

Treats bipolar depression w/o triggering mania.

Has not demonstrated efficacy in treating acute mania.

Question 18

1st line for patients w/ acute severe mania

Answer 18

Lithium or valproate

Question 19

Dopamine antagonists

Answer 19

Haloperidol (haldol)

Chlorpromazine (thorazine)

Question 20

Dopamine antagonist SE

Answer 20

Parkinsonian sx
Dyskinesia
Tardive dyskinesia
Dysautonia
DYstonia
Akathisia

Question 21

Cogentin

Answer 21

Relieves SE of dopamine antagonists.

Anticholinergic med

Question 22

Serotonin-dopamine antagonists (SDAS)

Answer 22

Atypical antipsychotics
Second generation antipsychotics
Fewer SE
No extrapyramidal SE

Question 23

SDAS SE

Answer 23

Weight gain
Glucose intolerance
DM
Hyperlipidemia

Question 24

Clozapine brand name

Answer 24

Clozaril
SDAS
Weight gain

Question 25

Olanzapine brand name

Answer 25

Zyprexa
SDAS
Weight gain

Question 26

Ziprasidone brand name

Answer 26

Geodon
SDAS
Less weight gain

Question 27

Risperidone brand name

Answer 27

RIsperidol

Question 28

Which SDAS causes least weight gain?

Answer 28

Ziprasidone (Geodon)

Question 29

Aripiprazole brand name

Answer 29

Abilify

Question 30

Quetiapine brand name

Answer 30

Seriquel

Drowsiness