biorisk mitigation strategies Flashcards
can be based on either a hazard and/or a threat.
risk
object that can cause harm
hazard
person who has intent and/or ability to cause harm to other people, animals, and/or the institution
threat
likelihood of an event or incident w/ a hazard that has consequence
risk
the probability an
event occurring
Likelihood
the severity of
an event
Consequence
key comoponent of biorisk management
biorisk assessment, biorisk mitigation, performance
process of identifying hazards and evaluating risks associated with biological agents and toxins, taking into account the adequazy of any existing controls and deciding whether or not the risks are acceptable
biorisk assessment
actions and control measures that are put into place to reduce or eliminate the risks associated with biological agents and toxins
biorisk mitigation
implementation of entire biorisk management system
performance
process of risk assessment
identify hazard/threat –> determine consequence
of an identified risk –> identify all existing controls and any additional ones that need to be applied.
risk identification/threat identification
assessment
likelihood or consequence evaluation
assessment
elimination or substitution
engineering controls
administrative controls
practice and procedures
ppe
mitigation
control, assurance, improvement
performance
what is the hierarchy of controls from most effective to least effective
elimination, substitution, engineering controls, administrative vontrols, PPE
Physically remove the hazard
elimination
replace the hazard
substitution
isolate people from the hazard
engineering controls
change the way people work
administrative control
protects woker with ppe
ppe
shared comitment of management and employee to ensure safety of work environment
safety culture
encourages every individual in an org. to project a level of awareness and accountability for safety
safety culture
a _____ permeates all aspect of work environment
culture of safety
a _____ permeates all aspect of work environment
culture of safety
type of cabinets
fume hood, laminar flow cabinet (LFC), Biohazard safety cabinet (BSC)
- Removes toxic chemical
FUME HOODS
No HEPA filter -> not for
biohazard agents
fume hoods
Product protection (no
personnel protection)
Laminar Flow Cabinets
Not for biohazard
agents or chemical
fumes
laminar flow cabinet
Class I BSC:
Personnel and Environment Protection
Class II & III BSC:
Personnel, Product and Environment Protection
BSCs provide —–
for work with —–material or ———
when they are properly maintained and used
in conjunction with good laboratory
technique
Biological safety cabinet
Personnel protection is provided through a
continuous stream of inward air, known as
inflow
helps prevent aerosol from escaping through front opening
inflow
exhaust air is exhausted into
surrounding containment zone or directly to atmosphere
air is —- to protect the environment
hepa-filtered
HEPA stands for
High Efficiency Particulate Air
ULPA stands for
ULPA: Ultra Low Penetration Air
- HEPA: 99.99% - at ?? microns
0.3
- ULPA: 99.999% - at —-??
0.12 microns
The “classical” definition of
HEPA filter is 99.97% at 0.12
microns, but nowadays all BSC and
LF in US use 99.99% at 0.3 m.
T OR F
FALSE. The “classical” definition of
HEPA filter is 99.97% at 0.3
microns, but nowadays all BSC and
LF in US use 99.99% at 0.3 m
Removes a broad range of airborne
contaminants:
HEPA/ULPA Capability
impurity ion can affect
integrated circuit speed
specialized clothing or equipment worn by an employee to provide protection against a hazard (e.g., infectious agents and toxins).
PPE
completely isolates the employee from the laboratory environment.
Biosafety level 4 positive pressure suit
The use of specific PPE required is determined through a
risk assessment
determines the type of ppe required
characteristics of the infectious agent or toxin being manipulated and the type of laboratory procedures performed
If there is a risk of creating an infectious biological aerosol (suspension of very fine particles or droplets in the air), use of
the proper respirator will prevent the worker from inhaling the infectious aerosol. This work can also be conducted in a biosafety cabinet to contain any aerosols created.
Describes microscopic droplets that may contain infectious agents or toxins, similar to the droplets produced by a sneeze or a cough.
aerosol
Some laboratory procedures including ——-, ——, ——–, ——————-and ———can produce aerosols.
Some laboratory procedures including sonication, centrifugation, vortexing, flow cytometry, fluorescence-activated cell sorting (FACS) and homogenization can produce aerosols.
