biopsych Flashcards

1
Q

localisation of function AO1

A

The brain has two symmetrical hemispheres which control some of our physical and psychological functioning
eg language linked to the left hemisphere

  • theory that different areas of the brain are responsible for different processes/behaviours
    (broca + wernicke)

cortex of both hemispheres divided into 4 lobes - occipital, parietal, temporal, frontal lobe

frontal lobe = motor area controlling voluntary movement of the opposite side of the body
- damage of this leads to loss of control over fine movements

both parietal lobes = somatosensory area processes sensory information from the skin
seperated from motor area via central sulcus

occipital lobe = visual area processes and receives visual information
- right visual field (of each eye) sends info to left visual cortex and left visual field sends info to right visual cortex
damage to hemisphere -> blindness or partial blindness

temporal lobes = auditory area analysing speech based information
damage -> partial hearing loss

language restricted to left hemisphere:
damage to brocas area - left frontal lobe (brocas aphasia) -> speech lacks fluency with conjunctions (and/the)
damage to wernickes area (left temporal lobe) responsible for language understanding -> nonsense words

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2
Q

localisation of function eval - evidence from neurosurgery

A

Evidence from neurosurgery:

neurosurgery targets parts of the brain involved in mental disorders
eg: cingulotomy for OCD
dougherty et al reported on 44 individuals with OCD, 32 weeks post surgery = 30% has successful response to surgery and 14% a partial response

  • suggests behaviours linked to serious mental disorders are localised and can be treated by isolating that part of the brain causing the issue

+ case study of phineas gages accident affecting frontal lobe causing personality shift
- first form of evidence linking frontal lobe to personality
BUT is a case study so isnt generalisable to all (extreme scenario)

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2
Q

localisation of function eval - language may not just be localised to wernicke/broca

A

language may not be localised to just wernicke and brocas area:

dick and tremblays interview found only 2% of researchers think wernicke/brocas area is entirely involved in language control

advances in brain imaging like fMRIs means neural processes in the brain can be studied more objectively

language function distributed holistically in the brain - not isolated to W/B areas

Even found in right hemisphere

contradicting localisation theory

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2
Q

localisation of function eval - evidence from brain scans + counter

A

Evidence from brain scans:

peterson et al used brain scans to demonstrate how wernickes area was active in listening tasks and brocas during reading tasks
objective measures = valid evidence

+ other studies have shown that semantic memory and episodic memories are linked to different parts of the prefrontal cortex

BUT lashley removed different areas of the cortex in rats learning a maze and found no difference in the rats ability to learn the route
suggests learning requires every part of the cortex rather than being confined to one area
- learning = more holistic disapproving localisation of function theory

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2
Q

hemispheric lateralisation AO1

A

idea that the two halves of the brain are functionally different and that each hemisphere has functional specialisations

language = lateralised as broca+wernicke’s area = left hemisphere (B= left frontal W= left temporal)

Some functions arent lateralized:
motor area appears in both hemisphere but is contralateral

vision = contralateral (right hemisphere controls left side of body)
+ ipsilateral - LVF of BOTH eyes connected to right hemisphere and RVF of BOTH eyes connected to left hemisphere
- slightly different perspective = greater depth perception

Sperry - split brain research on 11 ppts undergone split brain surgery where corpus callosum was removed (prevents communication between hemispheres)
presented info to one hemisphere only by flashing a stimulus in either of the visual fields

Presenting a word (cat) in the left visual field (connected to RH) meant the patient wasn’t able to verbally express what he saw as the language centres are located in the LH.
However, they were able to draw a picture of a cat, using their left arm (connected to their RH)

Concluded some functions are lateralised eg left hemisphere is more verbal

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3
Q

hemispheric lateralisation eval - research support + counter

A

Research support:
fink et al used PET scans to identify active areas of brain during visual processing tasks

global elements of an image (whole forest) showed activity in RH more but looking at finer details (one tree) showed activity in LH

suggest that in connected brains some aspects of visual processing show hemispheric lateralisation

but lowered validity as research only looks at visual processing

BUT
Nielsen et al- analysed brain scans from 1000+ people 7–29 years old
people used certain hemispheres for certain tasks
but no evidence of a dominant side or LH as analyser and RH as synthesiser
suggesting notion of left and right brained people is incorrect

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4
Q

hemispheric lateralisation eval - hard to establish causal relationships

A

a limitation of Sperry’s research is that it is hard to establish causal relationships.

For example, the control group he used can be described as neurotypical, meaning none of those participants had epilepsy.

This is a problem because this becomes a confounding variable because any differences Sperry found between the split-brain participants and the control group may be a result of the epilepsy

Therefore, it is hard to determine whether the unique features of the participants’ cognitive processing abilities were actually due to hemispheric lateralisation or not.

+ used quasi experiment so sperry didnt manipulate any variables - low internal validity

Small sample size and age could be a confounding variable

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5
Q

hemispheric lateralisation eval - adaptive + counter

A

Adaptive:
allows 2 tasks to be performed simultaneously - useful for animal survival instincts
roger et al showed lateralised chickens could find food and watch predators but normal chickens couldnt

BUT not adaptive as
it would not benefit an individual for their brains to be too fixed in structure in case of injury
non-specialised areas in opposite hemispheres can take over functions, following damage caused by illness or trauma = plasticity

lateralized functions are more flexible rather than fixed and brain plasticity is more important as it can deal with brain damage

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6
Q

plasticity AO1

A

Brain plasticity is the ability to form neural connections in response to new demands on the brain

synaptic connections increase as a child and decrease in adulthood by strengthening frequently used ones and deleting rarely used connections = synaptic pruning

maguire studied taxi drivers brain after study of the knowledge
found more grey matter in prosterior hippocampus than control associated with navigation

Found preparation for “ the knowledge test “ altered brain structure
+ positive correlation with time spent as a driver and how pronounced brain changes were

+ draganski - medical students 3 months before+after exam showed changes in prosterior hippocampus and parietal cortex due to learning

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7
Q

plasticity eval - negative behavioural consequences

A

Negative behavioural consequences:

60-80% of amputees experience phantom limb syndrome causing extreme discomfort due to cortical reorganisation in the somatosensory cortex

brains ability to adapt to damage isnt always useful

BUT useful for language learning where the brain molds to increase the size of the left interior parietal cortex enabling bilinguacy

suggests plasticity isnt useful when coping with unatural issues but beneficial in most cases

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8
Q

plasticity eval - lifelong plasticity

A

Lifelong plasticity:

plasticity usually decreases with age
bezzola found 40 hours of golf training of 40-60 year olds led to increased motor cortex activity with fMRIs compared to control

plasticity can help reduce age related cognitive decline

research can be used to treat patients with neurodegnerative diseases like alzheimers

increasing neural connections acts as treatment decreasing rate of cognitive decline
a

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9
Q

plasticity eval -affected by environmental change

A

Affected by environmental change:

SCN regulates the sleep/wake cycle
shrinks in all animals during spring and expands throughout autumn (includes humans) (Tramontin and Brenowitz)
This enables better adaption to day length

BUT research mainly on songbirds - question whether cycles are the same in birds and humans
as humans have less adaptive pressure to develop biological mechanisms to adapt to environment

more research needed on humans and plasticity linked to environemental change

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10
Q

functional recovery AO1

A

form of plasticity occuring after trauma
transfer of roles from damaged areas to undamaged by transfer of synaptic connections close to area of damage

fast process post trauma (spontaneous recovery) but slows down as time goes on

secondary neural pathways revived to enable functioning as usual + structural changes(doidge et al)

  • axonal sprouting = new nerve endings connect with undamaged ones forming new neural pathways
  • denervation supersensitivity = neurones with similar roles aroused to compensate for the ones lost (but increases sensitivity to pain)
  • recruitment of homologous areas on opposite side of the brain = some tasks still perform eg: brocas area damaged on LH can still decode language from RH
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11
Q

functional recovery eval - real world applications

A

Real world applications:

understanding processes of plasticity -> improvements in neurorehabilitation

axonal growth via functional recovery encourages new treatments to be trialed

eg: constraint induced movement recovery used on stroke patients where they continue to use the affected body part while the unaffected body part is restrained

research used to improve treatments for patients using functional recovery

allows medical professionals to develop new therapeutic interventions to help patients following brain damage

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12
Q

functional recovery eval - recovery affected by cognitive reserve

A

cognitive reserve affects recovery:

level of education affects recovery rates
schneider et al found longer time spent in education (linked to cognitive reserve) led to faster recovery

+ greater chances of disability free recovery

40% of those achieving DFR had spent 16+ years in education compared to only 10% with DFR with less than 12 year education

BUT results may be due to chance or other factors such as health as 10% still achieved DFR even with less cognitive reserve

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13
Q

functional recovery eval - validity issues

A

Validity issues:

banerjee found stem cell treatment on 5 patients with TACS led to recovery in all patients compared to 4% usually

BUT, small sample size as only 5 ppts plus no control group to compare to (difficult to match patients based on extent of damage)

results cannot be generalisable (similar to politician gabby giffords case where she was longitudinally studied but was a one off case - shot point blank)

rich data obtained which was useful for brain plasticity but cannot explain all people -

temperament may have affected her recovery = low external validity

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14
Q

fMRI

A

fMRI - detects changes in oxygen levels in blood flow occurring due to activity within the brain
active areas of brain require more oxygen directing greater blood flow to area in use

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15
Q

fMRI adv

A

no radiation (unlike PET) so risk free + non invasive
images also have high spatial resolution (detailed)
provides a clear picture of brain activity

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16
Q

fMRI disadv

A

expensive compared to other methods
low temporal resolution due to lag so fmri isnt representative of in the moment brain activity

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17
Q

EEG

A

record of impulses produced by brain activity on electrodes
can detect neurological abnormalities such as epilepsy, insomnia or tumours

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18
Q

EEG adv

A

high temporal resolution (unlike fmri)
+ diagnoses many sleep disorders + tumours

19
Q

EEG disadv

A

cant pinpoint exact source of neural activity (results from millions of neurones)

20
Q

ERP

A

ERP - electrophysiological response of the brain to a specific sensory/cognitive/motor event
ERP formed from EEGs leaving behind brainwaves triggered by event (rather than broad area)

21
Q

ERP adv

A

more specificity of neural processes compared to EEGs
high temporal resolution (compared to fmri)
used to understand working memory

22
ERP disadv
backround noise must be entirely eliminated + lack of standardisation in methodology between studies
23
Post mortem
- analysis of brain after death to determine whether observed behaviours during lifetime can be linked to brain abnormalities
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post mortem adv
foundation for key processes in brain eg: wernicke found links between language and brain before scans existed
25
post mortem disadv
correlation doesnt equal causation unclear if brain abnormality affected behaviour when alive ethical issues of consent when dead eg: HM
26
circadian rhythm AO1
A circadian rhythm is a biological rhythm that lasts for around 24 hours and is governed by internal factors, such as the suprachiasmatic nucleus (endogenous pacemakers), and external factors, such as light (exogenous zeitgebers). eg: sleep/wake cycle and core body temperature. sleep/wake cycle is controlled by our internal biological clock, or SCN, which uses light information (exogenous zeitgeber) to reset itself every day. Siffre conducted a study to investigate the importance of light on our circadian rhythm. He spent several months underground, deprived of natural light and sound. He found that his biological rhythm settled down to around 25 hours SCN lies above optic chiasm providing info about light to the eye (light resets SCN) core body temperature fluctuates by about 2 degree during the course of the day, with its lowest at 4AM and peaks around 6PM folkard et al - 12 ppts placed in dark cave for 3 weeks sleeping and waking at set times -unknown to them - the clock was being sped up to a 22 hour day instead of 24 and only one ppt was able to comfortably adjust to change therefore strong circadian rhythm cant easily be overriden by exogenous zeitgebers
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circadian rhythm eval - practical applications
Improve medical treatments: body processes like HR rise and fall during day - linked to circadian rhythm led to chronotherapeutics (treatment corresponding to persons rhythms) eg: taking aspirin at night reduces risk of heart attack occurring in early mornings therefore circadian rhythms can increase effectiveness of drugs Shift school day: delaying start time of school day has been proposed to suit teenagers circadian rhythms proper sleep leads to greater class average BUT isnt suited for everyone affected by individual differences where some people sleep late or wake up early therefore changes wont suit everyone + disruptive to parents critics say teenagers will still sleep later and changes to the day may not actually help
28
circadian rhythm eval - difficult to make generalisations
Difficult to make generalisations: A limitation of research into circadian rhythms is that it is difficult to make generalisations For example, Siffre’s study consisted of only himself as the sample and research has shown that there are major individual differences in sleep/wake cycles (between 13 to 65 hours) These differences aren’t just between individuals, but also vary with a person as they age, as Siffre observed his own sleep/wake cycle slowed down as he got older Therefore, it is difficult to make meaningful generalisations regarding sleep/wake cycles based on the research that was done.
29
infradian rhythms AO1
infradian = more than 24 hour cycles eg menstruation or SAD menstrual cycle: endogenous system affected by exogenous factors stern + mcklintock - studies 29 women with irregular periods gathered pheromones from 9 women from armpit and treated with alcohol and frozen before being applied to upper lip of ppts found 68% synchronised to odour donors cycle SAD: seasonal affective disorder triggered by shorter daylight hours in winter melatonin secreted from pineal gland until dawn longer nights means more melatonin secreted having knock on effects on serotonin production - depressive symptoms
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infradian eval - menstrual synchrony adaptive
Menstrual synchrony adaptive: stern and mClintock observed menstrual synchrony which can be explained via natural selection advantageous for women to menstruate + give birth together allows babies who have lost their mothers to survive with others breast milk - improves chances of survival + support for child with large community of mothers to help synchronisation = adaptive strategy
30
infradian eval - methodological issues
Methodological issues: menstrual cycle is affected by many factors like stress, changes in diet or exercise - acts as confounding variables synchronisation may occur due to chance rather than manipulation of pheromones explains why other studies have been unable to replicate findings - low internal validity + only 68% of women saw synchronisation in periods so not true for all -> unsure how long synchronisation with odour donor lasts for
31
infradian eval - real world applications
Real world applications: treatments for SAD= light therapy - box simulates very strong light to reset the body's internal clock reduces effects of SAD in 80% of people safe + no side effects compared to antidepressants BUT causes eyestrain - headaches relapse rate of 46% over successive winters, compared to 27% in a comparison group receiving CBT suggests that light therapy may be an effective short-term treatment but additional treatments may be required for future
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ultradian rhythms AO1
Ultradian: ultradian rhythm is anything less than 24 hours sleep wake cycle 5 stages of sleep lasting 90 minutes 1-2 = light sleep but easily woken (1) - high frequency alpha waves and short amplitudes (2) - alpha waves with occasional changes = sleep spindles 3-4 = hard to wake people up - slow wave sleep delta waves with lower frequency + higher amplitude 5 = rapid eye movement paralysed body but brain activity similar to being awake dreams occur
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ultradian rhythms eval - explains age related changes to sleep
Explains age related changes to sleep: researchers found slow wave sleep reduces with age growth hormones produced during SWS so older people are deficient in this sleep deficit may explain various impairments in old age like reduced alertness practical value as meditation and relaxation techniques can increase SWS to reduce impairments - treatment for older people
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ultradian rhythms eval - individual differences
Individual differences: significant variation between people tucker - large difference in duration of each sleep stage between people particularly stage 3/4 differences are likely to be biologically determined difficult to determine normal duration of sleep - findings cant be generalised
35
endogenous exogenous AO1
The suprachiasmatic nucleus (SCN) = endogenous pacemaker, responsible for maintaining circadian rhythms located in the hypothalamus, receives light information from the optic chiasm In the day, the SCN passes light information to the pineal gland which inhibits melatonin production, a hormone which induces sleep. At night, melatonin production increases DeCoursey destroyed SCN inside the brains of 30 chipmunks and returned them to their natural habitats. This greatly impacted their sleep/wake cycle as many of them were killed by predators Exogenous zeitgebers = external factors in the environment that reset biological clocks, such as light and social cues. Research has demonstrated that light can be detected by skin receptors and affect our sleep/wake cycle even when that information isn’t taken up by the eyes 15 ppts woken during night and light shone behind their knee found a deviation of sleep cycle by up to 3 hours = light is a strong exogenous zeitgeber even without the eyes influence on brain Social cues, such as mealtimes and bedtimes, start influencing a baby's sleep/wake cycle around 16 weeks. Adapting to local sleep and bedtimes is an effective way of entraining your circadian rhythm and beating jet lag. e
36
ultradian rhythms eval - high internal validity
High internal validity: control over extraneous variables like noise ensures IV affects DV - causal relationship between sleep and behaviour BUT involves being attached to machines which are not representative of ordinary sleeping in people Low external validity: Controlled factors like temperature = artificial conditions hard to generalise data obtained from controlled sleep studies in lab settings to sleep in an everyday context.
37
endogenous exogenous eval - pace makers cant be studies in isolation
Pacemakers cant be studies in isolation: unable to study endogenous pacemakers in isolation total isolation studies like siffres cave study are rare normally endogenous and exogenous factors interact together - doesn't make sense to separate for research absence of one could inhibit the other - untrue findings Lowers validity Exogenous affected by environment: exogenous Zeitgebers dont have same influence in all environments arctic circle inuits have little light in winter and little darkness in summer - but have similar sleep patterns all year around despite half the year in darkness therefore sleep wake cycle is primarily governed by endogenous factors that can override environmental changes in light
38
endogenous exogenous eval - oversimplified (SCN not the only clock)
Oversimplified (SCN not the only clock): Eg: research has shown that there are many circadian rhythms (peripheral oscillators) in many organs and cells in the body that are influenced by the SCN and can act independently. researchers were able to change the feeding patterns of mice and alter the circadian rhythms of the liver by 12 hours, whilst leaving the SCN rhythm unaffected. suggests the sleep/wake cycle isn’t solely governed by the SCN and there are other complex influences affecting our circadian rhythms.
39
endogenous exogenous eval - social cues couldnt alter sleep wake cycle in cave study
Case study- social cues couldnt alter sleep wake cycle: man blind from birth (15% of the time cannot detect changes in light) rhythm of 24.9 hours couldnt be changed despite regular meal times and bedtimes therefore it isnt true that social cues compensate for a lack of light both may be needed BUT individual differences can affect results
40
endogenous exogenous eval -ethical issues
Ethical issues: mammalian brains in both humans and hamsters mean results can be generalisable BUT most of chipmunks in decourseys study died, were removed from habitat and harmed + ralph destroyed hamsters SCN from foetus and normal hamsters cycle was disrupted unlikely theyd survive in the wild n
41
nervous system AO1
Nervous system: collects, responds and processes information in the environment coordinates the working of different cells in the body CNS (central): consists of brain and spinal cord cerebral cortex (3mm thick) covers brain in mammals spinal cord = extension of the brain - passes messages to and from brain + links nerves to PNS PNS (peripheral): transmits messages to (muscles/glands) and from CNS via neurones PNS subdivided into ANS/SNS ANS - autonomic = involuntary actions controlling vital functions of body like breathing/digestion/arousal consists of sympathetic (activates fight or flight) + parasympathetic ( returns body to resting state) nervous systems SNS - somatic = recieves info from sensory receptors and controls voluntary muscle movement
41
fight or flight response
Fight or flight response: endocrine + ANS work together - stressor causes hypothalamus to activate pituitary gland triggering sympathetic branch of ANS change from parasympathetic state to sympathetic state -adrenaline released from adrenal glands causing physiological changes like increased HR for arousal - once threat has passed, body returns to parasympathetic state = rest and digest state n
41
location of neurones
location: cell body of motor neurones found in CNS but long axons form part of PNS sensory neurones found in PNS in ganglia (clusters) mainly relay neurones in body found in brain + visual system s
41
neurones + structure
Neurones: nerve cells that process and transmit messages through electrical and chemical signals sensory neurons (long dendrites and short axons) motor neurons (short dendrites and long axons) relay neurons (short dendrites and short or long axons) cell body = nucleus containing genetic information dendrites = branches carrying impulses from neighbouring neurones towards cell body axon = carries impulses from cell body down the length of the neuron - covered in myelin sheath speeding up electrical transmission - gaps in myelin sheath = nodes of ranvier speed up transmission terminal buttons = communicate with neighbouring neurones across synapses l
42
synaptic transmission
Synaptic transmission: stimulus activates neurone so inside of cell becomes +ve charged momentarily causing an action potential creating an electrical impulse travelling down axon towards neuron end. neighbouring neurones communicate via transmission of impulses across a synapse in groups called neural networks once impulse reaches pre-synaptic terminal (end of neurone) triggering release of neurotransmitter from synaptic vessles neurotransmitter crosses synapse and is taken up by post-synaptic receptor site (one direction) on next neurons dendrites + chemical message converted back into impulse each neurotransmitter has diff structure and functions eg: ACh released at motor neuron meeting muscle causing contractions
43
summation
Summation: serotonin = inhibitory -> inhibition in receiving neuron makes the neuron more -ve and less likely to fire - decreases likelihood post synaptic neurone will pass on impulse adrenaline = excitatory -> excitation of postsynaptic neurone makes neurone more +ve and more likely to fire - increases likelihood post synaptic neurone will pass on impulse inhibitory and excitatory influences are summed for net effect on post synaptic neuron net effect inhibitory = less likely to fire net effect excitatory = more likely to fire action potential only triggered after summation of influences reaches its threshold to carry impulse forward