Biology of Cancer Cell

Question 1

At what age approximately does cancer exponentially increase?

Answer 1

55-60 years

Question 2

What causes cancer

Answer 2

Accumulation of many genetic mutations

Question 3

What best explains why some people remain cancer free and others develop cancer when exposed to a carcinogen?

Answer 3

Individual genetic variations

Question 4

At which point in the cell cycle does the Rb tumor suppressor gene function?

Answer 4

At the first restriction point, R, during phase G1

Question 5

What type of changes in DNA of a gene cause oncogenes?

Answer 5

Deletion or point mutation
Gene amplification that results in more copies of the gene

Question 6

What are major ways that tumor suppressor genes inhibit proliferation of cells?

Answer 6

Cause cell senescence or stimulate apoptosis

Question 7

Newer therapeutic approaches of treating cancer are aimed at activating what system in our body?

Answer 7

Immune

Question 8

Changes in cell function associated with development of cancer

Answer 8

Cancer alters cell function

Question 9

“Driver” mutations

Answer 9

Change base - change amino acid - change function

Question 10

“Passenger” mutations

Answer 10

Genes that don’t matter if you mutate them - doesn’t change protein

Question 11

Why p53 it’s important in cell function

Answer 11

Figures out if gene replication is good
If there is mutation, can it be fixed?
If not, apoptosis