Biology Chapter 12: Genetics and Evolution Flashcards
Chromosomes
contain genes in a linear sequence
Alleles
Alternate forms of a gene
dominant allele
masks recessive allele and requires only one copy to be expressed.
Recessive allele
Requires two copies to be expressed - masked by a dominant allele
genotpe
combination of alleles one has at a given genetic locus.
phenotype
observable manifestation of a genotype
Penetrance
the proportion of a population with a given genotype.
Medel’s first law of segregation
an organism has two alleles for each gene, which segregates during meiosis, resulting in gametes carrying only one allele for a trait.
Mendel’s second law of independent assortment
state that the inheritance of one allele does not influence the probability of inheriting a given allele for a different trait.
Griffith experiment
demonstrated the transforming principle, converting non-virulent bacteria to virulent bacteria by exposure to heat-killed virulent bacteria.
Avery-MacLeod-McCarthy experiment
demonstrated that DNA is the genetic material because degradation of DNA led to a cessation of bacterial transformation
Hershey-Chase
confirmed that DNA is the genetic material because only radiolabeled DNA could be found in bacteriophage-infected bacteria.
Gene pool
All of the alleles in a given population.
Point mutations
substitute one nucleotide for another
Frameshift mutation
moving the three letter transcriptional reading frame
Silent mutation
no effect on the protein
Missense mutation
results in the substitution of one amino acid for another.
Nonsense mutation
results in the substitution of a stop codon for an amino acid.
Frame shift
caused by insertions and deletions
Translocation
a segment of DNA is swapped with a segment of DNA from another chromosome
Genetic leakage
a flow of genes between species through hybrid offspring
Genetic drift
occurs when the composition of the gene pool changes as a result of change
Founder effect
results from bottlenecks that suddenly isolate a small population, leading to inbreeding and increased prevalence of certain homozygous genotypes.
Monohybrid cross
Accounts for one gene