Biological Explanations of Schizophrenia - Genetics Flashcards
What did Gottesman’s research show?
as genetic similarity increases, so does the probability of sharing schizophrenia
% risk of developing Sz from general population
1%
% risk of developing Sz from parents
6%
% risk of developing Sz from children
13%
% risk of developing Sz from DZ twins
17%
% risk of developing Sz from MZ twins
48%
Name the 3 researches that show evidence that supports genetic influence on Sz
Gottesman (1991) Family studies
Tienari et al (2000) Finland Adoption study
Ripke et al (2014) Sz is polygenetic
Gottesman (1991) Family studies
Findings
The closer the genetic relationship, the greater the likelihood of developing symptoms too
Gottesman (1991) Family studies
% findings
both parents w/ Sz - 48% concordance rate
1 parent w/ Sz - 13% concordance rate
Tienari et al (2000) Finland Adoption study
method
Looked at 164 adoptees whom biological mother diagnosed w/ Sz
197 control group (no diagnosis)
Tienari et al (2000) Finland Adoption study
Findings
11 adoptees (6.7% developed Sz
4 controlled adoptees developed Sz
Tienari et al (2000) Finland Adoption study
Children of parents with a diagnosis of Sz are still at higher risk of developing Sz when adopted into families w/ no history of Sz
Ripke et al (2014) Sz is polygenetic
method
compared 37,000 patients w/ 113,000 controls
Ripke et al (2014) Sz is polygenetic
findings
108 different genetic variations are linked with increased risk of Sz
included genes linked w/ neurotransmitters
define polygenetic
number of genes that work together
