Biological explanations Flashcards

1
Q

what are concordance rates?

A

-likelihood that if one family member has schiz that other one will.

-in psych look at twin and adoption studies to assess concordance rates for schiz.

-look at the extent to which greater genetic similarity between family members is associated with likelihood of both family members level schiz.

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2
Q

what are candidate genes?

A

-not a ‘schizophrenic gene’ but several individual genes involved with a risk of inheriting schiz (polygenic)

-diff studies identified diff candidate genes involved in schiz. so its aetiologically heterogeneous

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3
Q

what does aetiologically heterogeneous mean?

A

different combinations of the genes can lead to the condition

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4
Q

Ripke et al (2014) - candidate genes

A

-Found 108 diff genetic variations associated with increased risk of schiz. Some of these genes coded 4 functioning of neurotransmitters including dopamine.

-Be noted that having their genes doesn’t mean one will definitely develop schiz.

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5
Q

Gottesman - running in families

A

as genetic similarity increases so does prob of sharing schiz:
-identical twins (48%)
-fraternal twins (17%)
-children (13%)
-siblings (9%)
-parents (6%)

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6
Q

neural explanations

A

-development of schizophrenia is related to structural and functional brain abnormalities.

-includes activity of brain structures such as ventral striatum and neurotransmitters such as dopamine.

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7
Q

what is dopamine

A

-dopamine is a neurotransmitter which operates in brain and is responsible for many of our feelings/behaviours

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8
Q

what is the original dopamine hypothesis?

A

-original dopamine hyp stated patients with schiz have an oversensitivity to actions of dopamine.

-high numbers of D2; hypersensitive receptors; excess amounts of dopamine.

-thought they experienced hyperdopaminergic dopamine in subcortex (central brain).

-excess amount of dopamine receptors in Brocas area (speech production) -speech poverty + hallucinations.

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9
Q

what does hyperdopaminergic mean?

A

too much dopamine

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10
Q

what’s the more updated dopamine hypotheses?

A

-patients with schizophrenia may experience hypodopaminergic dopamine In cortex.

-Goldman-Rakic et al (2004) identified low levels of dopamine in prefrontal cortex which is responsible for decision making and may lead to -ve symptoms such as avolition.

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11
Q

what does hypodopaminergic mean?

A

too little dopamine

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12
Q

neural correlates

A

-ventral striatum linked to motivation and anticipated of reward.

-abnormalities in ventral striatum may be involved in the development of avolition

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13
Q

Juckel et al (2006) - neural correlates

A

-found lower levels of activity in ventral striatum than in controls.

-also found -ve correlation between activity levels in ventral striatum and the severity of overall -ve symptoms.

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14
Q

Allen et al (2007)- neural correlates

A

-scanned brains of individuals experiencing auditory hallucinations + compared to control group whilst they identified pre-recorded speech as theirs or that of others.

-lower activity levels found in superior temporal gyrus (STG) + anterior cingulate gyrus (ACG) of ppl experiencing auditory hallucinations.

-STG deals with speech processing

-ACG deals with error detection.

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15
Q

Curran et al

A

Amphetamines increase levels of dopamine and make schizophrenics symptoms work but also produce schizophrenic symptoms in ppl who aren’t diagnosed.

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16
Q

Tauscher et al

A

Antipsychotic drugs reduce dopamine activity and therefore improve schizophrenic symptoms.