Biologic Therapy Flashcards
What are monoclonal antibodies?
Immunoglobulins derived from a monoclonal cell line and which have a defined specificity
Which drugs are monoclonal antibodies?
Pamitumumab, cetuximab, trastuzumab, bevacizumab, farletuzumab
What monoclonal Ab inhibit EGFR?
Cetuximab, pamitumumab
What is EGF?
Endothelial growth factor is a transmembrane tyrosine kinase protein growth factor
What agent targets HER2/ERBB2?
Trastuzumab (herceptin)
What test should be used to confirm number of DNA gene copies of ERBB2 prior to initiating treatment?
FISH is confirmatory
What does herceptin target?
HER2 receptor
What is the mechanism of action of Bevacizumab?
Antibody against VEGF, preventing it from binding VEGF
What is the most common side effect of Bevacizumab?
Hypertension
What is the mechanism of Farletuzumab?
Folate receptor alpha, monoclonal antibody
What small molecule inhibitor is an oral RAF and VEGF inhibitor?
Sorafenib
What small molecule inhibitor is a PDGFR and VEGFR inhibitor?
Sunitinib
What small molecule inhibitor is an EGFR inhibitor?
Gefitinib (iressa)
What small molecule inhibitor is an EGFR and ERBB2 inhibitor?
Lapatinib
What small molecule inhibitor targets c-kit, bcl-abl and PDGFR2 (as well as stem cell factor)?
Imatinib
