Bioglass

Question 1

Give some material characterization techniques of HCA

Answer 1

● XRD (crystallinity)
● FTIR (bonding)
● SEM (structure and morphology)
● XPS (surface bonding)
● TEM (more detailed structure)

Question 2

Briefly give and describe an in-vitro assessment of Bioactivity

Answer 2

Immersion in SBL (simulated body fluid)

Bioglass → immerse in SBF → detect Ca and P in SBF → decrease in Ca and P → HCA is forming

Question 3

Some applications and uses of Bioglass

Answer 3

● Dental Filling
● Coating in implant to improve biocompatibility
● Carriers (Therapeutic Ions)
● Growth Factors
● Bone space-fillers

Question 4

Describe the formation of HCA from bioglass

Answer 4

① SBF + Bioglass (exchange of alkali ions with hydrogen from SBF)
② Network dissolution and formation of SiOH bonds
③ Silica-gel polymerization SiOH + SiOH → Si - O - Si
④ Chemisorption of amorphous Ca + PO₄ + CO₃
⑤ Crystallization of HCA Layer

Question 5

What is SBF?

Answer 5

● SBF stands for simulated body fluid

● It has a similar composition of blood plasma

Question 6

What is the composition of Bioglass? and when can we call it bioactive glass?

Answer 6

● SiO₂ + Na₂O + CaO + P₂O₅

● Forms an HCA layer on contact with SBF

Question 7

Give some method to Synthesize Bioglass

Answer 7

1. Melt Derived

2. Sol-gel method

Question 8

Differentiate Bioglass HCA versus Lab Synthesized HCA

Answer 8

● Lab syn HCA are more crystallize: Doesn’t degrade → Restricted
● Lab syn HCA are made in a non-ideal biological situation
● Bioglass HCA simulates biological condition