Biocomposites Flashcards
Typical Method For organ growth
- Xenograft-use of an animal part without the gene
that affects the human immune system - Tissue Engineering- persuading the body to regenerate
or repair tissues that Fail to regenerate or heal
spontaneously
Factors/ Elements to consider for Scaffold Fabrication
● Manufacturing Route
● Performance-Time Degradation
● Regulatory Approval
Characteristic of a Good scaffold
- Bioactivity
- Biocompatibility
- Resolvable ability
- Ease of Manufacture
- Adequate Mechanical Properties
Composite Scaffold basic composition
Mixture of Resolvable Polymer (PDLLA, PGA or PLGA) and Bioactive element
Advantages of making a Composite Scaffold
- Improved osteoconductivity via enabling of HA formation on the surface thus ideal site for bone re-growth
- Control of Polymer degradation rate and counter act acidic degradation
- Enhanced mechanical properties
- Avoidance of Growth Factor Addition
Characterization of scaffolds (composite)
● Bioactive Behavior
● Surface Analysis (SEM, Raman, XRD, FTIR)
● Mechanical and thermal Behavior
● Degradation Behavior
Give an example of how to fabricate a scaffold (composite)
Can be done via Electrophoresis Deposition
Bioglass deposits into the Polymer Foam via electric field
What are the 2 classification of Bioactivity
Osteoconductivity (Class B)
Osteoinductivity (productivity) (Class A)
Describe Osteoconductivity
A type of Bioactivity:
- Local surface growth HA-layer
- physico-chemical
- no capability to induce NEW BONE
Describe Osteoinductivity
A type of Bioactivity that:
- High Bioactivity Index
- acts directly on cells
- induce bone growth
- bonds to soft’s hard tissue
Importance of Porosity
● Scaffold for tissue engineering
● Non-loading implant application
● Bone will grow within interconnected pores
● Carrier for therapeutic ions
● Can be used to modify the necessary Young’s modulus (E)
How to reach Young’s modulus for bones from materials
Porosity can be used to tailor the Young’s modulus of a glass or ceramic to that of Bone
