biofilm 1 - caries Flashcards

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1
Q

what is erosion caused by

A
  • weak acids
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2
Q

what causes acid production

A
  • bacteria biofilm and fermentable carbohydrates
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3
Q

what 4 factors are needed for caries

A
  • saliva
  • diet
  • microbiota
  • tooth
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4
Q

how does caries progress

A
  • microorganisms adhere to tooth surface
  • they survive and grow = not washed away with saliva)
  • biofilm forms
  • complex plaque forms = made up of whole range of species
  • acid
  • caries
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5
Q

what is streptococcus mutans

A
  • microorganisms
  • clear link between presence o it and caries
  • linked to high sugar diet
  • the odontopathogen
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6
Q

why is S mutans associated with caries

A
  • glycolytic systems
  • EPS/sucrose metabolism
  • attachment mechanisms
  • greater acidogenicity/aciduricity
  • ecological competitiveness at low pH
  • genomic characteristics
  • has ability to modulate behaviour
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7
Q

does S mutans always cause caries

A
  • not definite but there is a link

- some people can have it and no caries, other can not have it and still have caries

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8
Q

what factors relate to the cariogenicity of s mutans

A
  • produces water soluble and insoluble extracellular polysaccharides from sucrose which help in the colonisation of tooth surfaces by consolidating microbial attachment
  • ability to initiate and maintain microbial growth and to continue acid production in sites of low pH
  • rapid metabolism of sugars to lactic and other acids
  • can attain critical pH for enamel demineralisation quicker than any other bacteria
  • produces intracellular polysaccharide which acts as food store when dietary carbohydrates are low
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9
Q

what are genitic contributions to caries devleopment

A
  • salivary composition and constituents may elevate or depress caries risk
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10
Q

what study proved that fermentable carbohydrate are important for caries

A

-vipeholm study = 1945-1955

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11
Q

what are some cariogenic foods

A
  • crisps
  • biscuits
  • cooked starches = stick around on teeth for longer
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12
Q

what is important for determining cariogenic potential

A
  • oral retentiveness
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13
Q

what factors help remineralisation

A
  • saliva
  • fluoride source
  • plaque control
  • diet modification
  • these produce more calcium, phosphate and fluoride
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14
Q

does bacteria differ in different areas of the mouth

A
  • yes

- mouth isn’t a homogenous group of bacteria

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15
Q

what does placenta microbiome look like

A
  • a lot lie mothers

- what organisms you have initially in your system has a key role in how you progress

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16
Q

what are the influencing factors of microbiome when born

A
  • human genes
  • pregnancy term
  • delivery method
  • feeding method
  • maternal
17
Q

what are some microbial flora associated with caries

A
  • actinomyces
  • bifidobacterium
  • lactobacillus
  • veillonella
  • prevotella
  • S. parasanguins
18
Q

what oral bacteria can predict alzheimers

A
  • spirochaetes

- porphyromonas gingival

19
Q

what oral bacteria can predict perio

A
  • red complex pathogens = P. gingivalis
  • arc heal methanogens
  • proteobacteria
20
Q

what oral bacteria can predict caries

A
  • S. mutans
  • lactobacillus
  • non-mutans streptococcus
21
Q

what oral bacteria can predict CVD

A
  • P. gingival
  • P. endodontalis
  • prevotella intermedia
  • prevotella nigrescens
  • campylobacter rectus
22
Q

what oral bacteria can predict CF

A
  • streptococcus oralis

- other strep

23
Q

what oral bacteria can predict oesophageal cancer

A
  • tannerella forsythia
  • p. gingival
  • streptococcus pneumonia
24
Q

what oral bacteria can predict colorectal cancer

A
  • lactobacillus
  • rothia
  • fusobacterium nuclaetum
25
Q

what oral bacteria can predict diabetes

A
  • aggregatibacter
  • neisseria
  • gemella
  • porphyromonas
  • filifactor
  • eubacterium
26
Q

what oral bacteria can predict pancreatic cancer

A
  • p. gingivalis
  • leptotrichia
  • aggregatibacter actinomycetemocomitans
27
Q

what oral bacteria can predict RA

A
  • veillonella
  • atopobium
  • prevotella
  • lactobacillus salivarius
  • p. gingivalis
  • rotha mucilaginosa
  • rothia aerial