biochemsitry 2 Flashcards
How does philadpelia chromosome occur?
Translocation of material beween chromsome 9 and chromosome 22
How does cystic fibrosis occcur?
Defective CFTR ion channel , resulting in chloride ions accumulating in the cell
How is sickle cell disease caused?
The A base is changed to T for the beta chain of haemoglobin, distroting red blood cells
What did Griffith do ?
used different strains of bacteria (virulent and non-virulent)and injected into mice
What did Griffith find
The mice with the virulent strain were killed , those with the non-virulent strain lived
what did griffith prove
that something from the dead cell trasnformed living cell
what did avery prove
That it was DNA that caused the transformation
What was the live rough strain and heat killed smooth strain treated with in Averys experiment?
DNAse
What did Hershey ans Chases experiment show
That the DNA from the T2 enters into the E.Coli enabling it to produce its own coat protein
What is a nucleoside
A surgar and a base
What is dATP
a nucleotide
What bases are purines
A and G
What bases are pyrimidines
C and T
How many hydrogen bonds between A and T
2
How many hydrogen bonds between G and C
3
what type of handed helix is DNA
right handed
what type of helix is B-DNA
right handed
What type of helix is A-DNA
right handed
What type of helix is Z-DNA
left handed
how is A-DNA formed
formed when DNA is dehydrated
How is miRNA transcribed
Transcribed from DNA by RNA pol II
What is the polypeptide rule ( little phrase that lecture phrase)
NCaCo
How are amino acids joined together
Via a condensation reaction , to join the carboxyl group of one AA to the amino group of the next
What group is produced when an amine group reacts with a carboxylic acid
Amid group
What is tRNA and what does it do
its an adaptor , connects the amino acids to the nucleic acids
Whta are the three words to describe the genetic code
-universal
-Degenerate
-Non overlapping
What are the 7 side chains in a protein
R1,R2,R3,R4,R5,R6,R7
What side chains in the section of a protein are hydrophobic and hydrophilic
R1,R2,R5 and R6 are hydrophobic
R3,R4 and R7 are polar
