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Medicine > Biochemistry > Flashcards

Biochemistry Flashcards

1
Q

Wernicke-Korsakoff

A

Thiamine / Vitamin B1 deficiency

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2
Q

Primary lipid of myelin

A

Galactocerebroside (Galc!

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3
Q

Fatty acid is joined to sphingosine via ______ linkage to form a ceramide.

A

Amide

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4
Q

Sphingomyelinase deficiency

A

Niemann-pick Disease

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5
Q

Major glycosphingolipid of brain and other nervous tissues

A

Cerebroside

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6
Q

Rate-limiting step in cholesterol synthesis

A

HMG-CoA to mevalonate
(HMG-CoA reductase)

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7
Q

Number of Carbons in cholesterol

A

27

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8
Q

Deficiency in Smith-Lemli-Opitz syndrome

A

7-dehydrocholesterol reductase

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9
Q

Alkylphospholipid

A

Platelet Activating Factor

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10
Q

Orlistat MOA

A

Reversible lipase inhibitor

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11
Q

Zellweger syndrome: defect in ______

A

Peroxisomes

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12
Q

Deficiency in Gaucher Disease

A

B-Glucosidase (Glucocerobrosidase)

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13
Q

Selenium deficiency cardiomyopathy

A

Keshan disease

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14
Q

Dietary deficient in Menkes syndrome

A

Copper

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15
Q

Rate limiting step of the urea cycle

A

CPSI (carbamoyl phosphate synthetase I)

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16
Q

Oxidative deamination of glutamate occurs in the __________.

A

Liver mitochondria

17
Q

Major gluconeogenic amino acid

A

Alanine

18
Q

Urea cycle occurs in which organ?

A

Liver

19
Q

Hartnup disease:
impaired transport of what amino acid

A

Tryptophan

20
Q

Enzyme associated with gyrate atrophy of choroid and retina

A

Ornithine transaminase

21
Q

Parent porphyrin of heme

A

Protoporphyrin III

22
Q

Rate limiting enzyme in heme production

A

ALA synthase
(Aminolevulinate)

23
Q

Only pathway that produces CO

A

Heme catabolism

24
Q

Rachitic rosary - rib prominence

A

Rickets

25
Q

Dermatitis
Diarrhea
Dementia

A

Pellagra (Vit B3 - Niacin deficiency)

26
Q

Vit B12 deficiency (cyanocobalamin)

A

Pernicious anemia

27
Q

Disease due to body’s inability to absorb tryptophan

A

Hartnup Disease

28
Q

Anemia due to deficiency in Folic acid (Vit B9)

A

Megaloblastic anemia

29
Q

Frosted glass cytoplasm

A

Monocytes

30
Q

The only non protein component of the ETC

A

Ubiquinone

31
Q

______ binds to lipoic acid of pyruvade dehydrogenase complex making it inactive

A

Arsenic

32
Q

Enzyme inhibited by Fluoroacetate

A

Aconitase (citrate —> isocitrate)

33
Q

Enzyme inhibited by Arsenite and Ammonia

A

A-ketoglutarate dehydrogenase (a-ketoglutarate —> succinyl CoA)

34
Q

Different configuration around 1 specific carbon syom (except the carbonyl atom)

A

Epimer (ex: glucose and mannose)

35
Q

Different configuration around the carbonyl atom

A

Anomers

36
Q

Structures that are mirror images of each other

A

Enantiomer aka Stereoisomers or optical isomers

37
Q

Compounds that have the same chemical formula

A

Isomers (ex: D-glucose, D-fructose)

Medicine (9 decks)

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