Biochemistry

Question 1

Wernicke-Korsakoff

Answer 1

Thiamine / Vitamin B1 deficiency

Question 2

Primary lipid of myelin

Answer 2

Galactocerebroside (Galc!

Question 3

Fatty acid is joined to sphingosine via ______ linkage to form a ceramide.

Answer 3

Amide

Question 4

Sphingomyelinase deficiency

Answer 4

Niemann-pick Disease

Question 5

Major glycosphingolipid of brain and other nervous tissues

Answer 5

Cerebroside

Question 6

Rate-limiting step in cholesterol synthesis

Answer 6

HMG-CoA to mevalonate
(HMG-CoA reductase)

Question 7

Number of Carbons in cholesterol

Answer 7

27

Question 8

Deficiency in Smith-Lemli-Opitz syndrome

Answer 8

7-dehydrocholesterol reductase

Question 9

Alkylphospholipid

Answer 9

Platelet Activating Factor

Question 10

Orlistat MOA

Answer 10

Reversible lipase inhibitor

Question 11

Zellweger syndrome: defect in ______

Answer 11

Peroxisomes

Question 12

Deficiency in Gaucher Disease

Answer 12

B-Glucosidase (Glucocerobrosidase)

Question 13

Selenium deficiency cardiomyopathy

Answer 13

Keshan disease

Question 14

Dietary deficient in Menkes syndrome

Answer 14

Copper

Question 15

Rate limiting step of the urea cycle

Answer 15

CPSI (carbamoyl phosphate synthetase I)

Question 16

Oxidative deamination of glutamate occurs in the __________.

Answer 16

Liver mitochondria

Question 17

Major gluconeogenic amino acid

Answer 17

Alanine

Question 18

Urea cycle occurs in which organ?

Answer 18

Liver

Question 19

Hartnup disease:
impaired transport of what amino acid

Answer 19

Tryptophan

Question 20

Enzyme associated with gyrate atrophy of choroid and retina

Answer 20

Ornithine transaminase

Question 21

Parent porphyrin of heme

Answer 21

Protoporphyrin III

Question 22

Rate limiting enzyme in heme production

Answer 22

ALA synthase
(Aminolevulinate)

Question 23

Only pathway that produces CO

Answer 23

Heme catabolism

Question 24

Rachitic rosary - rib prominence

Answer 24

Rickets

Question 25

Dermatitis
Diarrhea
Dementia

Answer 25

Pellagra (Vit B3 - Niacin deficiency)

Question 26

Vit B12 deficiency (cyanocobalamin)

Answer 26

Pernicious anemia

Question 27

Disease due to body’s inability to absorb tryptophan

Answer 27

Hartnup Disease

Question 28

Anemia due to deficiency in Folic acid (Vit B9)

Answer 28

Megaloblastic anemia

Question 29

Frosted glass cytoplasm

Answer 29

Monocytes

Question 30

The only non protein component of the ETC

Answer 30

Ubiquinone

Question 31

______ binds to lipoic acid of pyruvade dehydrogenase complex making it inactive

Answer 31

Arsenic

Question 32

Enzyme inhibited by Fluoroacetate

Answer 32

Aconitase (citrate —> isocitrate)

Question 33

Enzyme inhibited by Arsenite and Ammonia

Answer 33

A-ketoglutarate dehydrogenase (a-ketoglutarate —> succinyl CoA)

Question 34

Different configuration around 1 specific carbon syom (except the carbonyl atom)

Answer 34

Epimer (ex: glucose and mannose)

Question 35

Different configuration around the carbonyl atom

Answer 35

Anomers

Question 36

Structures that are mirror images of each other

Answer 36

Enantiomer aka Stereoisomers or optical isomers

Question 37

Compounds that have the same chemical formula

Answer 37

Isomers (ex: D-glucose, D-fructose)