BINDERS

Question 1

Sevelamer

Answer 1

Phosphate binder used to lowerserum phosphorus levels in CKD who are on dialysis (USA) or both dialysis and nondialysis dependent (Europe)

Question 2

Target phosphate levels for sevelamer

Answer 2

5.5mg/dl or less
Or
1.78mmol/L or less

Question 3

Sevelamer dosing

Answer 3

Initially 2.4–4.8g daily in 3 divided doses, dose to be given with meals and adjusted according to serum-phosphate concentration; usual dose 2.4–12g daily in 3 divided doses

Maximum used dose is 14g in dialysis patients