Bili/Jaundice

Question 1

What is bilirubin?

Answer 1

By-product of red blood cells breakdown

Question 2

Why do babies have higher billi production?

Answer 2

Because red blood cells break down faster and have shorter life span.
Newborns produce more than double than adults.
Babies also have slower bili removal through poop.

Question 3

Unconjugated bili

Answer 3

Indirect
Floating around in the blood by itself
It is fat soluble and can cross blood brain barrier-> kernicterus
It is bound to the protein albumin which delivers it to the liver. The bili that is free can go to the brain.

Question 4

Conjugated bili

Answer 4

Direct
Inside the liver
Water soluble and can’t go to the brain
If it’s not pooped out it can change again into unconjugated into the body

Question 5

What is hemolysis?

Answer 5

red blood cells
breaking down in the blood

Question 6

What is sepsis?

Answer 6

Whole body reaction to infection.
Infection spread in the blood

Question 7

Physiological jaundice

Answer 7

Normal
60% of term babies. Peak- 5-6 mg/dl
80% of preterm babies

Question 8

Cephalocaudal progression

Answer 8

From head to the toes

Question 9

Non physiological jaundice

Answer 9

In the first 24 hours is not normal!
Over production of bili
Or decreased clearance of bili

Question 10

Bili overproduction causes:

Answer 10

-abo incompebility
-bruising
-caphalohematoma