Big Picture Concepts

Question 1

Which anticoagulants have CYP interactions?

Answer 1

RAW

Rivaroxaban, Apixaban, Warfarin

Question 2

Which antiplatelets have CYP interactions?

Answer 2

CCTV
Clopidogrel
Cilostazol
Ticagrelor
Vorapaxar

Question 3

Which anticoagulants have P glycoprotein interactions?

Answer 3

READ

Rivaroxaban, Edoxaban, Apixaban, Dabigatran

Question 4

Which anticoagulants have reversal agents and what are they?

Answer 4

H-DEW
Heparin (protamine)
Dalteparin (protamine)
Enoxaparin (protamine)
Warfarin (Vit K)

Question 5

Which anticoagulants are contraindicated in severe hepatic dysfunction?

Answer 5

ADE

Apixaban, Dabigatran, Edoxaban

Question 6

Which antiplatelets are contraindicated in severe hepatic dysfunction?

Answer 6

DVT

Dipyridamole, Vorapaxar, Ticagrelor

Question 7

Which anticoagulants are contraindicated in severe renal dysfunction?

Answer 7

• The “new” agents (Rivar, Apix, Edoxaban)
• Dabigatran (DTI)
• Enoxaparin, Fondaparinux (LMWH)

Question 8

Which antiplatelets are contraindicated in severe renal dysfunction?

Answer 8

TED

Tirofiban, Eptifibatide, Dipyridamole

Question 9

Which antiplatelet is contraindicated in heart failure?

Answer 9

Cilostazol

Question 10

Which anticoagulant is contraindicated by weight and what is the threshold?

Answer 10

Fondaparinux (less than 50 kg)

Question 11

Which antiplatelet should be dose reduced by weight and what is the threshold?

Answer 11

Prasugrel (reduce if less than 60 kg)

Question 12

Which antiplatelet is contraindicated with prior stroke or TIA?

Answer 12

Prasugrel

Question 13

Which fibrinolytic has the shortest half life?

Answer 13

Reteplase (13-16 mins)