Beta-lactam Inhibitors

Question 0

Morgs covered by 1st gen cephalosporins

Answer 0

MSSA
Proteus
E. coli
Klebsiella

Question 1

1st gen cephalosporins

Answer 1

Cefazolin

Cephalexin

Question 2

2nd gen Cephalosporins

Answer 2

Cephamycin (cefoxitin, cefotetan, cefmetazole)

Cefuroxime - can cross BBB

Question 3

Morgs covered by 2nd gen cephalosporins

Answer 3

PEK + H. influenzae, Edwardsiella, Moraxella, Neisseria, Enterobacter aerogenes

Question 4

3rd gen cephalosporins for P. aeruginosa

Answer 4

CefTAZIdime

CefoPERAzone

Question 5

3rd eb cephalosporins for B fragilis

Answer 5

CefTIZOxime

Moxalactam

Question 6

1st line drugs for N gonorrhea

Co-drugs only for urethritis

Answer 6

Cefixime PO

Ceftriaxone IV

Question 7

Active against meningitis - 3rd gen cephalosporins

Answer 7

Ceftriaxone

CefoTAXIme

Question 8

morgs covered by 4th geb cephalosporins

Answer 8

P aeruginosa
Eneterobacter
S aureus
s pneumoniae

Question 9

4th gen cephalosporins

Answer 9

cefepime

Cefpirome

Question 10

Cephalosporins with methylthiotetrazooe group that should be given vitamin K

Answer 10

2nd gen:
CeFAMAndole
CefMETAzole
CefOTETAM

3rd gen:
CefoPERAzone

Fama Meta Otet Pera

Question 11

Beta lactam without gram + activity

Answer 11

AZTREONAM

A monobactam for gram negative rods only
Given IV
Excreted by tubular sectetion

Question 12

DOC for treatment of enetrobacter infections

Answer 12

Carbapenems:

Imipenem
Ertapenem
Doripenem
Meropenem

Question 13

Carbapenems are ineffective against?

Answer 13

Carbapenemase and metallo-B-lactamases

Question 14

Vancomycinis DOC for?

Answer 14

MRSA
2nd DOC for pseudomembranous colitis
Sepsis
Endocarditis

Question 15

AE in vancomycin

Answer 15

Red man or red neck syndrome due to release of histamine. Give via slow IV or decrease titration.

Question 16

Glycopeptide antibiotic derived from vancomycin. Potentially teratogenic.

Answer 16

Telavancin

Question 17

Inhibits enolpyruvate transferase

For uncomplicated lower UTI and cystitis in women

Safe for pregnant

Answer 17

Fosfomycin

Question 18

Inhibits alanine racemase and ligase enzyme

Answer 18

Cycloserine

Question 19

DOC for nongonococcal gonorrhea

Answer 19

Doxycycline and azithromycin for chlamydial urethritis

Question 20

H pylori regimen

Answer 20

PPI/H2 blocker + tetracycline or amoxicillin

Question 21

Tetracycline for meningococcal carrier state

Answer 21

Minocycline

Question 22

Tetracycline for SIADH

Answer 22

Demedocycline

Question 23

Tetracycline DOC for pxs with renal insufficiency

Answer 23

Doxycycline

Tigecycline

Question 24

Kidney toxicity associated with tetracycline use

Answer 24

Fanconi Syndrome - polydypsia, polyuria, low back pain

Question 25

DOCs for MRSA

Answer 25

Vancomycin

Tigecycline

Question 26

Resistant to tigecycline

Answer 26

Proteus and P aeruginosa

Question 27

Fda approved for skin infection, intrasbdomjn, CAP

Answer 27

Tigecycline

Question 28

Route of elimination of tigecycline

Answer 28

Bile

Question 29

MOA of macrolides

Answer 29

Inhibits translocation of peptidyle tRNA from acceptor to donor site via binding to 50s subunit

Question 30

MOR of gram + against macrolides

Answer 30

Methyltransferases alter drug 50s binding site

Question 31

MOR of gram - against macrolides

Answer 31

Esterases hydrolyze macrolides

Question 32

Best form of erythromycin

Answer 32

Erythromycin estolate

Question 33

AE of erythromycin

Answer 33

Diarrhea via activation of motilin receptors

Question 34

Prophylaxis prescribed by dentists for pxs with valvular heart disease during dental procedures

Answer 34

Erythromycin

Question 35

AE Of erythromycin in pregnant

Answer 35

Cholangitis

Question 36

Coverage of clarithromycin

Answer 36

MAC

H pylori