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Pharmacology I > BETA Blockers > Flashcards

BETA Blockers Flashcards

1
Q

What are the types of BETA adrenergic receptor antagonists

A
  • Non selective first generation
  • B1- selective second generation
  • Non selective third generation
  • B1-selective third generation
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2
Q

Non selective first generation antagonist drugs

A
  • Nadolol
  • propranolol
  • Timolol
  • Sotalol
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3
Q

B1-selective second generation antagonist drugs

A
  • Atenolol
  • Bisoprolol
  • Esmolol
  • Metoprolol
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4
Q

Non selective third generation antagonist drugs

A
  • Carvedilol
  • Labetalol
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5
Q

B1-selective third generation antagonist drugs

A

nebivolol

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6
Q

B1-Receptor heart function

A
  • heart rate
  • contractility
  • automaticity
  • conduction velocity
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7
Q

B2-Receptor function lungs

A
  • Bronchorelaxation
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8
Q

B1- receptor function in kidneys

A

renin release in kidneys

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9
Q

B2- receptor function in skeletal muscle

A
  • vasodilation
  • glycogenolysis
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10
Q

B2- receptor function in liver

A
  • Glycogenolysis
  • Gluconeogenesis
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11
Q

1/2 life of most B-antagonist

A

3-10 hours

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12
Q

what drug is the exception to the 1/2 life rule

A

Esmolol. Has a 1/2 life of 10 minutes

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13
Q

What drugs are not limited to varying degrees due to first pass metabolism

A

Betaxolol, Penbutolol, pindolol, sotalol

BePPiS

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14
Q

partial agonists

A

Depends on the activity of the sympathetic nervous system

EX: ligand for receptor is high the drug acts as antagonist, if it is low drugs can bind and activate it

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15
Q

what drugs block a1 receptors?

A

Labetalol, carvedilol

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16
Q

Vasodilator drugs

A

Nebivolol

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17
Q

Antioxidant drugs

A

Carvedilol

18
Q

BETA blocker effects on the eye

A

Reduce the intraocular pressure and decrease aqueous humor

19
Q

Why is it a bad idea to abruptly stop taking a BETA blocker

A

Your sympathetic nervous system is upregulated while taking which could cause a angina and increase risk of sudden death

20
Q

CNS effects with BETA blockers

A
  • Fatigue
  • Depression
  • sleep disturbances

No clear correlation

21
Q

Propranolol clinical use

A

Treats hypertension, Angina pectoris , cardiac arrhythmias, myocardial infraction, and pheochromocytoma, migrane, tremor

22
Q

propranolol adverse effects

A

cardiovascular, bradycardia, hypotension, heart failure, fatigue ,withdrawal symptoms, bronchospasm,

23
Q

timolol Clinical use

A

Treatment of glaucomal, which decreases aqueous humor concentration

(Timmy got sum glasses)

24
Q

metoprolol clinical use

A

Hypertension,Cardiovascular, angima, congestive heart
failure C.A.C.H

(slows heart)

25
Q

Metroprolol adverse effects

A

Overlap with propranolol . Less risk of bronchoconstriction. Mediated by B2 receptors

-blurry, bradychardia, hypotension : METRO TOOK A BEAN

26
Q

Esmolol clinical use

A

(B1) Administered when a beta blockade of short duration is desired. Mainly used to treat tachycardia

27
Q

Esmolol Adverse Effect

A

Ultra short acting 1/2 life of 8 minutes

28
Q

labetalol function

A

Antagonist for Beta 1 and Beta 2 receptors as well as Alpha 1 receptors

Treats hypertensive emergencies

29
Q

Labetalol clinical use

A

treats hypertension and treats hypertensive emergency

30
Q

carvedilol function

A

antagonist for Alpha 1 and both beta receptors, but has anti-oxidant and anti inflammatory type properties

  • Slows heart making it easier for blood pumping
31
Q

carvedilol clinical use

A

treat acute myocardial infraction, HTN, and heart failure

MHH

32
Q

Nebivolol function

A

B1 antagonist and stimulates nitric oxidate release.

33
Q

Nebivolol clinical use

A

treat hypertension

34
Q

drugs used following a myocardial infraction

A

Timolol, Propranolol, metoprolol

35
Q

advantages of beta blockers in cardiac arrythmias

A

slows ventricular response rates to atrial flutter and fibrillation

36
Q

advantages of beta blockers in heart failure

A

effective in reducing mortality in patients with chronic heart failure

37
Q

drugs to reduce heart failure

A

metoprolol, bisoprolol, and carvedilol

M.B.C

38
Q

What type of beta blockers are suitable for local use in the eye

A

Beta blockers that lack local anesthetic properties

39
Q

Beta blocker affects on hyperthyroidism

A

Beta blockers assist and make symptoms better in hyperthyroidism

40
Q

Beta blockers for migraines

A

propranolol, metoprolol, timolol: PMT
(same drugs used for post acute MI)

probably effective: atenolol, nadolol

41
Q

Beta blocker for anxiety and tremors

A

propranolol

42
Q

When choosing a beta blocker what must be considered

A

comorbidities such as diabetes or other diseases

Pharmacology I (12 decks)

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