BETA Blockers Flashcards
What are the types of BETA adrenergic receptor antagonists
- Non selective first generation
- B1- selective second generation
- Non selective third generation
- B1-selective third generation
Non selective first generation antagonist drugs
- Nadolol
- propranolol
- Timolol
- Sotalol
B1-selective second generation antagonist drugs
- Atenolol
- Bisoprolol
- Esmolol
- Metoprolol
Non selective third generation antagonist drugs
- Carvedilol
- Labetalol
B1-selective third generation antagonist drugs
nebivolol
B1-Receptor heart function
- heart rate
- contractility
- automaticity
- conduction velocity
B2-Receptor function lungs
- Bronchorelaxation
B1- receptor function in kidneys
renin release in kidneys
B2- receptor function in skeletal muscle
- vasodilation
- glycogenolysis
B2- receptor function in liver
- Glycogenolysis
- Gluconeogenesis
1/2 life of most B-antagonist
3-10 hours
what drug is the exception to the 1/2 life rule
Esmolol. Has a 1/2 life of 10 minutes
What drugs are not limited to varying degrees due to first pass metabolism
Betaxolol, Penbutolol, pindolol, sotalol
BePPiS
partial agonists
Depends on the activity of the sympathetic nervous system
EX: ligand for receptor is high the drug acts as antagonist, if it is low drugs can bind and activate it
what drugs block a1 receptors?
Labetalol, carvedilol
Vasodilator drugs
Nebivolol
Antioxidant drugs
Carvedilol
BETA blocker effects on the eye
Reduce the intraocular pressure and decrease aqueous humor
Why is it a bad idea to abruptly stop taking a BETA blocker
Your sympathetic nervous system is upregulated while taking which could cause a angina and increase risk of sudden death
CNS effects with BETA blockers
- Fatigue
- Depression
- sleep disturbances
No clear correlation
Propranolol clinical use
Treats hypertension, Angina pectoris , cardiac arrhythmias, myocardial infraction, and pheochromocytoma, migrane, tremor
propranolol adverse effects
cardiovascular, bradycardia, hypotension, heart failure, fatigue ,withdrawal symptoms, bronchospasm,
timolol Clinical use
Treatment of glaucomal, which decreases aqueous humor concentration
(Timmy got sum glasses)
metoprolol clinical use
Hypertension,Cardiovascular, angima, congestive heart
failure C.A.C.H
(slows heart)
Metroprolol adverse effects
Overlap with propranolol . Less risk of bronchoconstriction. Mediated by B2 receptors
-blurry, bradychardia, hypotension : METRO TOOK A BEAN
Esmolol clinical use
(B1) Administered when a beta blockade of short duration is desired. Mainly used to treat tachycardia
Esmolol Adverse Effect
Ultra short acting 1/2 life of 8 minutes
labetalol function
Antagonist for Beta 1 and Beta 2 receptors as well as Alpha 1 receptors
Treats hypertensive emergencies
Labetalol clinical use
treats hypertension and treats hypertensive emergency
carvedilol function
antagonist for Alpha 1 and both beta receptors, but has anti-oxidant and anti inflammatory type properties
- Slows heart making it easier for blood pumping
carvedilol clinical use
treat acute myocardial infraction, HTN, and heart failure
MHH
Nebivolol function
B1 antagonist and stimulates nitric oxidate release.
Nebivolol clinical use
treat hypertension
drugs used following a myocardial infraction
Timolol, Propranolol, metoprolol
advantages of beta blockers in cardiac arrythmias
slows ventricular response rates to atrial flutter and fibrillation
advantages of beta blockers in heart failure
effective in reducing mortality in patients with chronic heart failure
drugs to reduce heart failure
metoprolol, bisoprolol, and carvedilol
M.B.C
What type of beta blockers are suitable for local use in the eye
Beta blockers that lack local anesthetic properties
Beta blocker affects on hyperthyroidism
Beta blockers assist and make symptoms better in hyperthyroidism
Beta blockers for migraines
propranolol, metoprolol, timolol: PMT
(same drugs used for post acute MI)
probably effective: atenolol, nadolol
Beta blocker for anxiety and tremors
propranolol
When choosing a beta blocker what must be considered
comorbidities such as diabetes or other diseases
