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Cardio I - Pulm Meds, O2 Modalities, And Lab Values > Beta Agonists > Flashcards

Beta Agonists Flashcards

1
Q

Action

A

Bind to BETA2 receptors in the LUNGS –> increased smooth muscle relaxation and decreased inflammation

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2
Q

MOA

A

Block the BRONCHODILATION in the lungs caused by sympathetic NC stimulation and attach to receptors in the heart and lungs

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3
Q

Adverse effects

A

Tremor
TACHYcardia
HYPOkalemia
HYPERglycemia

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4
Q

Are adverse effects with beta agonists strong?

A

No, they are limited because of minimal systemic absorption and limited stimulation of B2 receptors on the HEART

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5
Q

Limited B2 stimulation on which organ causes beta agonists to have limited SEs?

A

HEART –> decreases systemic effects (along with decreased systemic absorption)

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6
Q

What happens with high-dose beta agonists?

A

There are higher risk of SEs because the drug diffuses into BS

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7
Q

Tremors are a SE for which type of beta agonist?

A

Nonselective (bc of increased sympathetic NS activation)

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8
Q

Why is TACHYcardia a SE of beta agonists?

A

Receptors in the SA node are stimulated

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9
Q

What are the names of some common short-acting beta agonists (SABAs)?

A

ProAir
Proventil
Ventolin (albuterol)

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10
Q

What is the suffix commonly associated with SABAs?

A

“-ol” like for BBs used to tx heart conditions

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11
Q

Why are SABAs used?

A

Active asthma flare because it bronchodilates the airways immediately

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12
Q

What are common forms of SABAs?

A

MDI
Nebulizer solution
Oral syrup
Oral tablet

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13
Q

SABA onset of action

A

5-10 min

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14
Q

SABA peak effect

A

MDI/neb: 1-2 hours

Oral: 0.25-3 hours

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15
Q

SABA duration of action

A

MDI/neb: 3-6 hours

Oral: 6-8 hours

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16
Q

SABA nebulizer vs pill…

A

Neb: straight to lungs (directly to target tissue so not as much systemic vasculature infusion, good absorption from capillaries)
Pill: increased systemic effects because in the BS, 1st pass effect

17
Q

What is the name for a common long-acting beta agonist (LABA)?

A

Serevent (salmeterol)

18
Q

What is the suffix commonly associated with LABAs?

A

“-ol”

19
Q

What form do LABAs come in?

A

DPI

20
Q

LABAs on set of action

A

30-60 min

21
Q

LABAs peak effect

A

2-3 hours

22
Q

LABAs duration of action

A

12 hours

23
Q

Why is there a black box warning associated with LABAs?

A

Increased risk of death when used as the only agent to treat asthma –> should be combined with inhaled steroid

24
Q

Is there a black box warning for LABAs when used to treat COPD?

A

No, they can be used as monotherapy to tx COPD

25
Q

Why would someone use a LABA for asthma or for COPD?

A

Take it every day to control mucus and edema - for maintenance

Cardio I - Pulm Meds, O2 Modalities, And Lab Values (5 decks)

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