Anticholinergics

Question 1

Action

Answer 1

Block action of acetylcholine on smooth muscle receptors

DECREASED BRONCHOCONSTRICTION and DECREASED MUCUS in the airways

Question 2

MOA

Answer 2

Block PNS receptors (decreased mucus) to help prevent bronchoconstriction

Question 3

Adverse effects

Answer 3

Dry mouth
Dizziness
Pharyngeal irritation
TACHYcardia

Question 4

Clinical uses

Answer 4

COPD maintenance
COPS exacerbations
Moderate to severe asthma exacerbations in ED

Question 5

Can they be used for COPD maintenance and during flares?

Answer 5

Yes

Question 6

What is the name of a long acting anticholinergic?

Answer 6

Spiriva (tiotropium)

Question 7

What is Spiriva (tiotropium)?

Answer 7

Long acting anticholinergic –> dry powder inhaler (DPI)

Capsule device

Question 8

Spiriva (tiotropium) onset of action

Answer 8

1 hour

Question 9

Spiriva (tiotropium) peak effect

Answer 9

3 hours

Question 10

Spiriva (tiotropium) duration of action

Answer 10

24 hours

Question 11

What is the name of a short acting anticholinergic?

Answer 11

Atrovent (ipratropium)

Question 12

What is atrovent (ipratropium)?

Answer 12

Short acting anticholinergic –> metered dose inhaler (MDI)

Can also be nebulizer solution

Question 13

Atrovent (ipratropium) onset of action

Answer 13

15 minutes

Question 14

Atrovent (ipratropium) peak effect

Answer 14

1-2 hours

Question 15

Atrovent (ipratropium) duration of action

Answer 15

2-5 hours