Airway Regulation Flashcards
Parasympathetic NS releases…
Acetylcholine (AcH)
AcH (in the parasympathetic NS) acts on…
Muscarinic M2 receptors
What is the action of the parasympathetic NS on the pulmonary system?
BronchoCONSTRICTION of the larger airways
Mucus secretion
What type of response is that of the parasympathetic NS?
Vagal (bronchoconstriction)
The sympathetic NC releases…
Catecholamines (epinephrine - E)
Catecholamines (epinephrine - E) (in the sympathetic NS) bind to…
B2 receptors
What is the action of the sympathetic NS on the pulmonary system?
BronchoDILATION –> stimulate smooth muscle relaxation and inhibition of mast cell release
What happen when the sympathetic NS is stimulated?
Smooth muscles relax and bronchoconstriction is blocked –> promotes bronchodilation
What action do mast cells have on the pulmonary system when they are released?
Edema/airway constriction
Is the action of mast cells (edema/airway constriction) blocked or promoted when the sympathetic NS is stimulated?
Blocked –> sympathetic NS stimulation inhibits mast cell release, so the edema and airway constriction that their release causes is blocked
When are mast cells activated?
Exposure to allergens
What do mast cells do after they are activated to cause edema and airway constriction?
Release PROinflammatory mediators (histamine and cytokines)
What happens after proinflammatory mediators are released by the mast cells once the mast cells are activated after being exposed to a trigger allergen?
They induce contraction, mucus secretion, and VASOdilation
What happens to the effects of the parasympathetic and sympathetic NS’s with pulmonary disease?
Sympathetic response is enhanced
Parasympathetic response is blocked
Mast cell activation is blocked
