Bergdahl- Chapter 20 Flashcards
describe the ducts of the endocrine system
no ducts ! they secrete substances directly into extracellular spaces around the gland
what is a half-life ?
time required to reduce a hormone’s blood concentration by a half, and gives an indication on how long its effect persists
how are steroid hormones different from amine and peptide hormones ?
they’re not soluble in blood plasma
what are 4 ways that a hormone can specifically target a cell ?
1) modify rate of intracellular protein synthesis by stimulating nuclear DNA
2) change rate of enzyme activity
3) alter plasma membrane transport with a second-messenger system
4) induce secretion
what is the first step in initiating hormone action ?
hormone-receptor binding
what are the three things that a target cell’s activation by a hormone depends on ?
1) hormone concentration in blood
2) number of target cell receptors for hormone
3) sensitivity or strength of union between hormone and receptor
what are 3 ways that a hormone can increase enzyme activity ?
1) stimulate its production
2) combine with it to alter its shape and ability to act, increasing or decreasing its catalytic effectiveness
3) activating inactive enzyme forms, therefore increasing total amount of active enzyme
what are 4 factors that determine plasma concentration of a hormone ?
1) quantity synthesized in host gland
2) rate of catabolism or secretion in blood
3) quantity of transport proteins present
4) plasma volume changes
what does “secreted amount” mean ?
the plasma concentration of a hormone
the sum of hormone synthesis and release by host gland, in addition to uptake by tissues and removal by liver and kidneys
can changes in plasma volume alter hormone concentration ?
yeah, independent of the host organ’s secretion rate
what is hormonal stimulation ?
hormones influencing secretion of other hormones (eg ACTH)
what is humoral stimulation ?
changing levels of ions and nutrients stimulate hormone release (ADH, insulin)
what is neural stimulation ?
neural activity affects hormonal release (catecholamines)
what does a mean concentration of a hormone at a given time indicate ?
not much. the half-life and the pattern of release is much more significant
what controls the 6 releasing factors (hypothalamic hormones) ?
neural input to the hypothalamus from anxiety, stress, physical activity
what is growth hormone’s main mission ?
to promote cell division and cellular proliferation throughout the body
in adults, what are the 3 ways that GH promotes protein synthesis ?
1) increase aa transport through membrane
2) stimulate RNA formation
3) activate ribosomes that increase protein synthesis
what energy sources does GH promote or inhibit?
less protein and carbs, more fat utilization
how does training affect GH?
extends GH’s action on target tissues
what mediates GH’s effects ?
Insulin-like Growth Factors
what is thyrotropin’s main role ?
thyrotropin = thyroid-stimulating hormone
controls hormone secretion by thyroid gland
what is adenocorticotropic hormone’s main use ?
acts directly to enhance fatty acid mobilization and stimulate protein catabolism and increase gluconeogenesis
what are the two hormones that mediate ACTH release ?
vasopressin and corticotropin-releasing hormone
what is prolactin’s main role ?
initiates and supports milk secretion from mammary glands
how do prolactin levels change in exercise ?
increase at high intensities and return to baseline within 45 min during recovery
how is prolactin involved in training adaptations ?
exercise-induced release may inhibit ovarian function and contribute to menstrual cycle alterations
what is the main role of gonadotropic hormones ? what are they called ?
stimulate male and female sex organs to grow and secrete hormones at faster rate
follicle-stimulating hormone and luteinizing hormone