Benzos Flashcards
Benzo
Class
Antiepileptic
Anxiolytic
Benzodiazepine
Diazepam/Valium
Indications
A-acute anxiety attack S-sedation for electrical therapy P- A-acute alcohol withdrawal S-seizure activity M-
Benzo
P-Dyn
Bind to benzodiazepine sites in GABA receptors
Potentiates GABA by increasing frequency of Cl channel opening
Increases seizure threshold, sedation
Decreases anxiety
Benzodiazepines
A/S
Hypotension, apnea, respiratory depression, decreased LOC, confusion, N/V
Benzodiazepines
Contraindications
Allergy, ETOH respiratory depression, shock, head injury, coma
Benzodiazepines
Precautions
Reduced dose in elderly
DILUTE, venous irritation
Flush line well
Benzodiazepines
Interactions
Increased effects with CNS depressants
Flumazenil is antidote
Diazepam/Valium
P-Dyn
Anxiety reduction
Skeletal muscle relaxant
Sedation
Seizure suppression
Diazepam/Valium
A/S
Hypotension, apnea, resp depression, decreased LOC, confusion, N/V
Diazepam/Valium
Contraindications
Allergy, ETOH, resp depression, shock, head injury, coma
Diazepam/Valium
Interactions
DILUTE
Increases effects with other CNS depressants
Easily precipitates with other drugs
Diazepam/Valium
Indications
Acute anxiety
Skeletal muscle spasms
Premed
Seizures/status epilepticus
Diazepam/Valium
Dose
Slow IV or IM
MAX- 30 mg
Sz- 5-10 mg q 10-15 PRN
Anxiety- 2-5 mg
Premed- 5-15 mg
Lorazepam/Ativan
Indications
Anxiety, premed, seizure
Lorazepam/Ativan
Dose
1-4 mg slow IV/IM x2-10 min
Q 15-20 MAX 8 mg
Midazolam/Versed
Indications
Premed, Adult/Peds seizure
Midazolam/Versed
Dose
Premed- 1-2.5 mg slow IV
Small increments PRN MAX 0.1 mg/kg
Seizure- 5 mg slow IV/IM (0.07-0.08 mg/kg)
Flumazenil/Romazicon
Class
Benzo antagonist
Flumazenil/Romazicon
P-Dyn
Direct benzo antagonist, specific for benzos
Flumazenil/Romazicon
Indications
Benzo overdose
Reversal of benzo sedation
Flumazenil/Romazicon
A/S
Seizures, agitation, N/V
Flumazenil/Romazicon
Contraindications
Allergy
TCA overdose
Stimulant intox
Flumazenil/Romazicon
Dose
- 2 mg x15 sec
- 3 mg q 30 sec
- 5 mgq 60 sec x4, max 3 mg
No peds
Diazepam/Valium
Peds Dose
5y> 0.2-0.5 mg/kg q 2-5 max5
>5y 1 mg q 2-5 m10, (0.1 mg/kg)
Lorazepam/Ativan
Peds Dose
PEDS- 0.05-0.1 mg/kg SLOW
Repeat x1 q 5-10 MAX 4 mg
Rectal 0.1-0.2 mg/kg
Midazolam/Versed
Peds Dose
Peds- seizure 0.1-0.15 mg/kg max 5
Sedation- 0.05-0.2 mg/kg