Benzodiazepines

Question 0

Flumazenil therapeutic use

Answer 0

• reverse sedative effect of benzos

- reverse effects of benzo overdose

Question 1

Flumazenil

Answer 1

• Benzo competitive antagonist
• Binds to benzo site on GABA receptor
• No effect on its own
• Prevents benzo from binding

Question 2

Buspirone

Answer 2

Partial agonist at 5-HT1a and 5-HT2 receptors

Question 3

Buspirone therapeutic use

Answer 3

Only treats generalized anxiety

Question 4

Advantages of Buspirone over Benzos:

Answer 4

• little sedative/euphoria
• no rebound anxiety or withdrawal
• no enhancing of CNS depressants
• little abuse potential
• Preg category B

Question 5

Disadvantages of Buspirone:

Answer 5

• 1-2 wks for anti anxiety effect
• no anticonvulsant or muscle relaxant effects
• no blocking withdrawal from other CNS depressants

Question 6

Side effects of Buspirone:

Answer 6

Dizzy, lightheaded, tachycardia, palpitations, nervousness, GI & parenthesis more frequent than Benzos