Benzodiazepines Flashcards

1
Q

Mechanism of action

A

Act at GABAa receptors

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2
Q

Lipid soluble?

A

Highly - well absorbed rectally

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3
Q

Metabolism and excretion

A

Liver metabolism
Excreted in urine

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4
Q

CNS effects

A

anti anxiety/ antipanic
Sedation - age dependant - reliable in very young, very old or very sick animals
centrally acting muscle relaxant - relives sphincter muscle spasm in cats with urethral obstruction
anti-convulsant
appetite stimulant in cats
NO ANALGESIA

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5
Q

CVS effects

A

Very little depression

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6
Q

Resp effects

A

Very little depression - unless combined with an opioid

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7
Q

Antagonist?

A

Flumazenil, duration 30-60 mins

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8
Q

Examples

A

Diazepam, Midazolam

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9
Q

Diazepam

A

painful when given IM
can be given rectally
seizure control
Rapid onset, short duration

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10
Q

Midazolam

A

IV, IM, SQ
rapid onset, short duration

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