Benzo Drugs Take 2

Question 1

Classification of Midazolam, Lorazepam, Diazepam

Answer 1

Benzodiazepines

Question 2

MOA of Midazolam, Lorazepam, Diazepam

Answer 2

GABA Allosteric

Question 3

Effects of of Midazolam, Lorazepam, Diazepam

Answer 3

Anxiolysis, sedation/hynposis, anticonvulsant activity, spinal cord mediatedd skeletal muscle relaxation, anterograde amnesia
Amnestic effect > sedation

Question 4

pKa of midazolam

Answer 4

6.2

Question 5

Midazolam

Answer 5

Water soluble with imidazole ring

Question 6

Induction IV Dose of Midazolam

Answer 6

0.02-0.04mg/kg

Question 7

PO Dose of Midazolam

Answer 7

0.4-0.8mg/kg

Question 8

Laryngospasm Dose of Midazolam

Answer 8

0.5-1mg

Question 9

Sedation Post-Op Dose of Midazolam

Answer 9

0.5-4mg

Question 10

Infusion Dose of Midazolam

Answer 10

1-7mg/hr

Question 11

Onset of Midazolam

Answer 11

30-60 seconds

Question 12

Peak Effect of Midazolam

Answer 12

5 mins

Question 13

Vd of Midazolam

Answer 13

Highly Lipid Soluble
Extensive Protein Bound
Rapid Re-Distribution

Question 14

Duration of Midazolam

Answer 14

30-60 mins

Question 15

Elderly and Obese with Midazolam

Answer 15

Have increase Vd

Question 16

Metabolism of Midazolam

Answer 16

Oxidation via CYP450

Question 17

Active Metabolites of Midazolam

Answer 17

1-hydroxymidazolam (50% effect)- rapidly conjugated

4-hydromidazolam (not enough)

Question 18

Clearance of Midazolam

Answer 18

Kidneys

Question 19

Elimination 1/ 2Life of Versed

Answer 19

1.9 Hours

Question 20

Fastest Elimination 1/2 Life

Answer 20

Midazolam