Barbs Drugs Take 2 Flashcards
Classification of Thiopental
Barbiturate
Thiopental is a
weak acid and water soluble salt
MOA of Thiopental
GABA allosteric
Thiopental Induction Dose
2-2.5mg/kg IBW
Clinical Indication of Thiopental
Infusion TBI
Thiopental Dose Considerations
Decrease dose in elderly, early pregnancy and obese
Thiopental Vd/onset
30 sec-2mins
Large Vd
Duration of Thiopental
4 mins
Metabolism of Thiopental
Hepatic Oxidation via CYP450
Thiopental Active metabolite
Pentobarbital (long 1/2 life)
PD of Thiopental
Burst Suppression and Isoelectric EEG decrease CMRO/ICP/CMRO Reverse Steel Effect Decrease MAP and CO Respiratory Depression Airway Reflexes Maintained Minimal Bronchodilation
Thiopental Contraindications
Porphyrias
Eliminaition 1/2 Life of Thiopental
11 hours
Thiopental Enzyme Inducer of what Drugs
anticoagulants, phenytoin, tricyclic antidepressants, endogenous corticosteroids, vitamin K
Arterial Administration of Thiopental
Emergency
Papverine
heparinization
arteriodilation (regional)
Classification of Methohexital
Barbiturate
Methohexital is a
weak acid
MOA of Methohexital
GABA allosteric
Induction Dose of Methohexital
1-2mg/kg
Rectal: 25mg/kg
Infusion: 50-150 mcg/kg/min
Clinical Use of Methohexital
ECT because it decreases the seizure threshold
Special Considerations of Methohexital
Infusions associated w/ seizures
Myoclonus
Volume of Distribution of Methohexital
Large Vd
Elimination of Methohexital
4 hours
PD of Methohexital
Decreases BP and CO (inotropy), respiratory. Minimal bronchodilation
