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Pharmacology > Barbs Drugs Take 2 > Flashcards

Barbs Drugs Take 2 Flashcards

1
Q

Classification of Thiopental

A

Barbiturate

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2
Q

Thiopental is a

A

weak acid and water soluble salt

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3
Q

MOA of Thiopental

A

GABA allosteric

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4
Q

Thiopental Induction Dose

A

2-2.5mg/kg IBW

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5
Q

Clinical Indication of Thiopental

A

Infusion TBI

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6
Q

Thiopental Dose Considerations

A

Decrease dose in elderly, early pregnancy and obese

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7
Q

Thiopental Vd/onset

A

30 sec-2mins

Large Vd

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8
Q

Duration of Thiopental

A

4 mins

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9
Q

Metabolism of Thiopental

A

Hepatic Oxidation via CYP450

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10
Q

Thiopental Active metabolite

A

Pentobarbital (long 1/2 life)

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11
Q

PD of Thiopental

A 
Burst Suppression and Isoelectric EEG
decrease CMRO/ICP/CMRO
Reverse Steel Effect
Decrease MAP and CO
Respiratory Depression
Airway Reflexes Maintained
Minimal Bronchodilation
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12
Q

Thiopental Contraindications

A

Porphyrias

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13
Q

Eliminaition 1/2 Life of Thiopental

A

11 hours

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14
Q

Thiopental Enzyme Inducer of what Drugs

A

anticoagulants, phenytoin, tricyclic antidepressants, endogenous corticosteroids, vitamin K

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15
Q

Arterial Administration of Thiopental

A

Emergency
Papverine
heparinization
arteriodilation (regional)

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16
Q

Classification of Methohexital

A

Barbiturate

17
Q

Methohexital is a

A

weak acid

18
Q

MOA of Methohexital

A

GABA allosteric

19
Q

Induction Dose of Methohexital

A

1-2mg/kg
Rectal: 25mg/kg
Infusion: 50-150 mcg/kg/min

20
Q

Clinical Use of Methohexital

A

ECT because it decreases the seizure threshold

21
Q

Special Considerations of Methohexital

A

Infusions associated w/ seizures

Myoclonus

22
Q

Volume of Distribution of Methohexital

A

Large Vd

23
Q

Elimination of Methohexital

A

4 hours

24
Q

PD of Methohexital

A

Decreases BP and CO (inotropy), respiratory. Minimal bronchodilation

Pharmacology (14 decks)

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